Molecular mechanisms in the establishment of disease transmission by invertebrate vectors

Projektinformationen

BACTINSECT

ID Finanzhilfevereinbarung: 301365

Projekt abgeschlossen

Startdatum 1 Juni 2013

Enddatum 31 Mai 2015

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 151 426,80

EU-Beitrag € 151 426,80

Koordiniert durch

FUNDACAO CALOUSTE GULBENKIAN
Portugal

Ziel

Symbiosis is a major adaptive process allowing bacteria to interact with other organisms to colonise diverse and adverse environments. The genetic mechanisms behind these symbioses are poorly understood despite the fact that some have a major weight on human health and/or welfare. The goal of this project is to investigate the molecular mechanisms involved in monospecific bacterial-host interactions, in particular those occurring between invertebrates and bacteria leading to disease transmission. As a tool, I will use a simple symbiosis model involving Drosophila melanogaster and Pectobacterium carotovorum (formerly Erwinia carotovora), two genetically tractable organisms which will enable the contributions from both the host vector and the bacterial infective agent to be studied. We predict that the genetic determinants of bacterial-host interactions do not differ much and in several cases may rely on a simple genetic basis: the acquisition of a single gene allowing bacteria to colonize the gut of the host. To confirm this hypothesis, we will study the role of EVF (Erwinia virulence factor) in the symbiotic relationship between P. carotovorum and D. melanogaster as well as that of EVF homologues in Photorhabdus luminescens and Xenorhabdus nematophila, both specific nematode symbionts and insect pathogens. In addition, we will dissect the cell-signalling systems, including bacterial quorum sensing, in the insect-borne transmission of P. carotovorum and study the impact of quorum-sensing interference (quorum quenching) in its prevention.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › cell biology › cell signaling
• natural sciences › biological sciences › microbiology › bacteriology
• natural sciences › biological sciences › biological behavioural sciences › ethology › biological interactions
• natural sciences › biological sciences › zoology › invertebrate zoology

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2011-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

FUNDACAO CALOUSTE GULBENKIAN

Kontakt Verwaltung

José Mario Leite (Mr.)

• EU-Beitrag: € 151 426,80
• Adresse: AVENIDA BERNA 45A ; 1067-001 LISBOA ; Portugal
• Region: Continente › Área Metropolitana de Lisboa › Área Metropolitana de Lisboa
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten