Objective
Treatment of Urinary Tract Infections (UTI) is currently initiated empirically because conventional diagnosis takes 2-3 days from sample to results. Moreover, the pharmaceutical pipeline is almost dry. Therefore, the last decade has globally witnessed a huge explosion of antibiotic (AB) resistance in Gram Negative Bacteria (GNB), which has drastically reduced the available AB therapy choices for UTI. The WHO considers this one of the major public health threats. Rapid detection of bacterial species and their AB susceptibility provides the main option to curb this development and prolong the lifetime of currently available antibiotics.
In ROUTINE, 3 SMEs and 2 Universities will develop a prototype benchtop instrument that will rapidly (< 30 min) detect bacteria and characterize key antibiotics resistance profiles of ESBL (extended spectrum beta lactamase) and carbapenemase producing GNB directly from the patient urine at the point of care in outpatients and hospitals at a low cost (~20 €/test) and with near 100% sensitivity and specificity.
Key factors to success are:
1. The consortium has an established collaboration through other projects
2. The starting point, builds on previous knowhow and the reader, cartridge and bioassay technologies developed within previous collaborations.
3. The “uncomplicated” raw urine sample material and the choice of technologies will ensure reaching the ground-breaking end goals in terms of assay time, cost, sensitivity, specificity and ease-of-use.
4. The designs, materials and processes used are familiar to regulatory authorities, which enable approval by e.g. FDA.
5. The 3 SMEs have experience in developing and bringing diagnostics products to the market.
The project will lead to 1) a complete, tested, POC system, and 2) a tailor-made software algorithm for detection of AB resistant GNB, delivering a revolutionary tool in patient treatment, reducing morbidity and mortality, and curbing the spread of AB resistance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences health sciences public health epidemiology epidemics prevention
- medical and health sciences clinical medicine urology
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2012-INNOVATION-2
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
100 44 Stockholm
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.