Objective Treatment of Urinary Tract Infections (UTI) is currently initiated empirically because conventional diagnosis takes 2-3 days from sample to results. Moreover, the pharmaceutical pipeline is almost dry. Therefore, the last decade has globally witnessed a huge explosion of antibiotic (AB) resistance in Gram Negative Bacteria (GNB), which has drastically reduced the available AB therapy choices for UTI. The WHO considers this one of the major public health threats. Rapid detection of bacterial species and their AB susceptibility provides the main option to curb this development and prolong the lifetime of currently available antibiotics.In ROUTINE, 3 SMEs and 2 Universities will develop a prototype benchtop instrument that will rapidly (< 30 min) detect bacteria and characterize key antibiotics resistance profiles of ESBL (extended spectrum beta lactamase) and carbapenemase producing GNB directly from the patient urine at the point of care in outpatients and hospitals at a low cost (~20 €/test) and with near 100% sensitivity and specificity.Key factors to success are:1. The consortium has an established collaboration through other projects2. The starting point, builds on previous knowhow and the reader, cartridge and bioassay technologies developed within previous collaborations.3. The “uncomplicated” raw urine sample material and the choice of technologies will ensure reaching the ground-breaking end goals in terms of assay time, cost, sensitivity, specificity and ease-of-use.4. The designs, materials and processes used are familiar to regulatory authorities, which enable approval by e.g. FDA.5. The 3 SMEs have experience in developing and bringing diagnostics products to the market.The project will lead to 1) a complete, tested, POC system, and 2) a tailor-made software algorithm for detection of AB resistant GNB, delivering a revolutionary tool in patient treatment, reducing morbidity and mortality, and curbing the spread of AB resistance. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health scienceshealth sciencespublic healthepidemiologyepidemics preventionmedical and health sciencesclinical medicineurologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.2.3.0-1 - Diagnostics for infectious diseases in humans Call for proposal FP7-HEALTH-2012-INNOVATION-2 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator KUNGLIGA TEKNISKA HOEGSKOLAN Address Brinellvagen 8 100 44 Stockholm Sweden See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Erika Appel (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITEIT ANTWERPEN Belgium EU contribution € 616 064,00 Address Prinsstraat 13 2000 Antwerpen See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Higher or Secondary Education Establishments Administrative Contact Herman Goossens (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MICROFLUIDIC CHIPSHOP GMBH Germany EU contribution € 358 800,00 Address Stockholmer strasse 20 07747 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Holger Becker (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data Q-linea Sweden EU contribution € 533 400,00 Address Dag hammarskjölds väg 5-75237 Uppsala See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Johan Stenberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FINBIOSOFT OY Finland EU contribution € 630 973,00 Address Linnoitustie 4a 02600 Espoo See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jani Huttunen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
