Objective
Fatty acid (FA) intake and its subsequent fate are implicated the two most prevalent diseases in the developed world, coronary heart disease and type 2 insulin-resistant diabetes. More than 300 million people world-wide live with type 2 diabetes, and its incidence is increasing rapidly, especially in developing countries. In Europe alone, direct medical expenses for type 2 diabetes totals more than 30 Billion € per year and more than 50% of these costs are related to hospitalization. This Career Integration Grant application outlines the PI’s research programme to use a non-linear vibrational imaging technique in order to explore the underlying FA dynamics during ectopic fat deposition and FA metabolism in muscle cells.
Ectopic fat appears in muscle of insulin-resistant, type 2 diabetics and also, paradoxically, in endurance trained athletes – who have acute insulin sensitivity. The methods developed in this proposal will provide a platform for answering many unresolved questions regarding FA dynamics in muscle cells from intake (and lipogenesis) to FA metabolism in both normal and insulin-resistant muscle cells. The scientific results gleaned from this research will provide new data about FA packaging into LDs and FA metabolism upon triggered lipolysis as a function of insulin activity levels. Furthermore, experiments investigating LD proximity to mitochondria in normal and insulin-resistant muscle cells will provide much needed data to help unravel the “athletes paradox” outlined above. The outcome of the PI’s research plan will reveal a link between FA processing and insulin resistance, which is critical for design of new therapeutics to treat type 2 diabetes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences biochemistry biomolecules lipids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.