Objective Fatty acid (FA) intake and its subsequent fate are implicated the two most prevalent diseases in the developed world, coronary heart disease and type 2 insulin-resistant diabetes. More than 300 million people world-wide live with type 2 diabetes, and its incidence is increasing rapidly, especially in developing countries. In Europe alone, direct medical expenses for type 2 diabetes totals more than 30 Billion € per year and more than 50% of these costs are related to hospitalization. This Career Integration Grant application outlines the PI’s research programme to use a non-linear vibrational imaging technique in order to explore the underlying FA dynamics during ectopic fat deposition and FA metabolism in muscle cells.Ectopic fat appears in muscle of insulin-resistant, type 2 diabetics and also, paradoxically, in endurance trained athletes – who have acute insulin sensitivity. The methods developed in this proposal will provide a platform for answering many unresolved questions regarding FA dynamics in muscle cells from intake (and lipogenesis) to FA metabolism in both normal and insulin-resistant muscle cells. The scientific results gleaned from this research will provide new data about FA packaging into LDs and FA metabolism upon triggered lipolysis as a function of insulin activity levels. Furthermore, experiments investigating LD proximity to mitochondria in normal and insulin-resistant muscle cells will provide much needed data to help unravel the “athletes paradox” outlined above. The outcome of the PI’s research plan will reveal a link between FA processing and insulin resistance, which is critical for design of new therapeutics to treat type 2 diabetes. Fields of science medical and health sciencesclinical medicineendocrinologydiabetesnatural sciencesbiological sciencesbiochemistrybiomoleculeslipids Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants" Call for proposal FP7-PEOPLE-2012-CIG See other projects for this call Funding Scheme MC-CIG - Support for training and career development of researcher (CIG) Coordinator MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV EU contribution € 100 000,00 Address HOFGARTENSTRASSE 8 80539 Munchen Germany See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Udo Schreiner (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
