Objective
The study of biologically relevant processes heavily relays on “small molecules”. Thus, the demand for novel chemical probes is of highest importance not only for chemistry, but also for closely related disciplines such as biology, medicine or material science. As the construction of complex molecular architectures from chemical building blocks still remains a far-from-routine task, the development of methodologies to increase the control over chemical reactivity and achieve molecular complexity with higher levels of efficiency has become one of the frontier challenges of chemistry in the 21st century.
NIGOCAT aims to substantially contribute towards this goal. The general objective of this proposal is the design, synthesis and application in catalysis of novel, nature-inspired gold(I) and gold(III)-catalytic tools able to mimic nature´s efficiency and exquisite taste for the synthesis and stereoselective functionalization of “small molecules”. The proposed research tackles three main challenges faced by current synthetic methods: 1. Efficient generation of structural complexity; 2. Selective C-H bond functionalization; 3. High levels of stereocontrol in asymmetric catalysis.
We aim to streamline the construction of molecular complexity based on modular, unprecedented multi-center gold factories. Our hypothesis is that the assembly of different reactive sites within a single catalyst will provide an increased level of efficiency in gold-orchestrated catalytic cascades from simple starting materials, thus mimicking the way nature assembles its complex primary metabolites. Second, we aim to tackle the flexible, selective functionalization of C-H bonds using novel metaloenzyme-inspired ligands on gold. Third, we aim to develop novel gold peptide-based catalytic systems as general tools able to provide high levels of absolute stereocontrol in gold catalysis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-StG_20111012
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
8006 Zurich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.