Objective
Biofunctionalization of materials for application in regenerative medicine constitutes a constantly expanding field that will introduce revolutionary changes in classical healthcare and drastically improve the quality of life of patients. In recent years, extensive research has focused on the development of new biomaterials with the ability to restore damaged parts of the body and enhance tissue regeneration. However, much of this challenging area of research remains to be explored. This is the case of orthopedic and dental implants, where a poor biointegration of implant materials is associated with limited long-term medical outcomes and implant failure. To overcome this issue, strong and stable biochemical and mechanical interaction between the implant surface and the surrounding bone tissue are required after the implant surgery.
This research project aims to design, develop and investigate novel biofunctionalized metallic materials (low elastic modulus Ti alloys) for their application as biomedical devices for bone osseointegration and regeneration. Functional biomolecules with defined bioactive motifs to selectively enhance cell adhesion and improve biointegration, as well as with antibacterial properties, will be immobilized covalently on the metal surface by using organosilanes as crosslinker molecules. Biofunctionalized surfaces will be fully characterized for physical properties, chemical composition and biological activity. In vitro biological studies will include adhesion, proliferation and differentiation of mesenchymal stem cells. The biomaterials displaying the best biological profiles will be implanted in minipigs to investigate their osseointegration properties in vivo and their potential to be used in the clinics.
This research project proposes a highly multidisciplinary approach combining high quality and excellence in the fields of Chemistry, Biochemistry and Material Science to overcome a major challenge in Medicine currently not addressed.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine odontology dental implantology
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology cells technologies stem cells
- engineering and technology industrial biotechnology biomaterials
- medical and health sciences medical biotechnology implants
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
08034 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.