Objective The advent of molecular reprogramming and the associated opportunities for personalised and therapeutic medicine requires the development of novel systems for on-demand delivery of reprogramming factors into cells in order to modulate their activity/identity. Such triggerable systems should allow precise control of the timing, duration, magnitude and spatial release of the reprogramming factors. Furthermore, the system should allow this control even in vivo, using non-invasive means. The present project aims at developing triggerable systems able to release efficiently reprogramming factors on demand. The potential of this technology will be tested in two settings: (i) in the reprogramming of somatic cells in vitro, and (ii) in the improvement of hematopoietic stem cell engraftment in vivo, at the bone marrow. The proposed research involves a team formed by engineers, chemists, biologists and is highly multidisciplinary in nature encompassing elements of engineering, chemistry, system biology, stem cell technology and nanomedicine. Fields of science medical and health sciencesmedical biotechnologynanomedicinemedical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologynanotechnologynano-materials Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-PE8 - ERC Starting Grant - Products and process engineering Call for proposal ERC-2012-StG_20111012 See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Host institution CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO EU contribution € 1 699 320,00 Address UNIVERSIDADE DE COIMBRA LARGO MARQUES DE POMBAL 3004 517 Coimbra Portugal See on map Region Continente Centro (PT) Região de Coimbra Activity type Research Organisations Principal investigator Lino Da Silva Ferreira (Dr.) Administrative Contact Silvia Sousa (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO Portugal EU contribution € 1 699 320,00 Address UNIVERSIDADE DE COIMBRA LARGO MARQUES DE POMBAL 3004 517 Coimbra See on map Region Continente Centro (PT) Região de Coimbra Activity type Research Organisations Principal investigator Lino Da Silva Ferreira (Dr.) Administrative Contact Silvia Sousa (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
