Objective "The focus of this research project will be on halogen bonding, namely any noncovalent interactions involving halogen atoms as electrophilic species (electron density acceptor sites, Lewis acids, halogen bonding-donors). In particular, the overall goal of the project will be to fully elucidate the capabilities and properties of halogen atoms as recognition “sticky” sites in the context of biomolecules.The general objective of this research project will be achieved through the application of a multi-dimensional approach to the understanding of the intermolecular interactions involving halogenated molecules in chemistry and biology. The programme of work will centre around three closely integrated and synergistic strands. The common theme is to exploit halogen bonding for the design of “smart” peptides and foldamers (Strand 1), the obtainment of complexes of polyhalogenated organic pollutants with serum proteins (Strand 2), and to assemble biomimetic sensors for polyhalogenated organic pollutants (Strand 3).For the first time a multidisciplinary team composed by synthetic chemists, small molecule crystallographers, biologists, physicists, and protein crystallographers will join forces around the fundamental issues of: a) contributing to the establishment of the nature and properties of halogen bonding in ligand/biomolecule systems; b) improving our understanding of long-distance intermolecular interactions and their role on the energy profiles of biochemical transformations; c) facilitating preparation of more rationally designed new halogenated drugs; d) allowing for the mechanistic understanding of reactivity of halogen-containing molecules for the development of efficient and ""green"" synthetic and bioremediation methods.The overall aim of this project is, therefore, to enlighten to the scientific community the potential that halogen bonding has to become a very powerful tool in the manipulation of molecular recognition phenomena in chemistry and biology." Fields of science engineering and technologyenvironmental biotechnologybioremediationnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsnatural scienceschemical sciencesinorganic chemistryhalogens Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Call for proposal ERC-2012-StG_20111012 See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Host institution POLITECNICO DI MILANO EU contribution € 1 129 000,00 Address PIAZZA LEONARDO DA VINCI 32 20133 Milano Italy See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Principal investigator Pierangelo Metrangolo (Prof.) Administrative Contact Samuele Paolo Bordogna (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all POLITECNICO DI MILANO Italy EU contribution € 1 129 000,00 Address PIAZZA LEONARDO DA VINCI 32 20133 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Principal investigator Pierangelo Metrangolo (Prof.) Administrative Contact Samuele Paolo Bordogna (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TEKNOLOGIAN TUTKIMUSKESKUS VTT Participation ended Finland EU contribution € 40 032,00 Address TEKNIIKANTIE 4 A 02044 VTT ESPOO See on map Activity type Research Organisations Administrative Contact Sinikka Soirinsuo (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AALTO KORKEAKOULUSAATIO SR Finland EU contribution € 223 968,00 Address OTAKAARI 1 02150 Espoo See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Administrative Contact Olli Ikkala (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
