The role of neuronal intracellular traffic in Alzheimer´s disease

Projektinformationen

TRAFFICINAD

ID Finanzhilfevereinbarung: 334366

Projekt abgeschlossen

Startdatum 1 April 2013

Enddatum 31 März 2017

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 100 000,00

EU-Beitrag € 100 000,00

Koordiniert durch

FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA
Portugal

Ziel

In neurons of Alzheimer’s disease (AD) there is an aberrant accumulation of beta-amyloid (Aβ) at synapses that renders difficult the formation of new memories for AD patients. Intracellular trafficking abnormalities have been implicated in Aβ accumulation. This research project aims to define how neuronal intracellular trafficking is mechanistically involved in Aβ accumulation that leads to AD. We will determine how the intracellular itinerary of the amyloid precursor protein in neurons influences the generation of Aβ. We will determine the intracellular trafficking of lysosomal hydrolases in neurons and their contribution to the lysosomal clearance of Aβ. Furthermore, we will investigate the mechanism whereby regulators of intracellular trafficking identified as risk-factors for AD contribute to Aβ accumulation. Finally, because aging is the most important risk factor for AD, we will determine if alterations in intracellular trafficking occur in aging, identifying a new mechanism of vulnerability to neurodegeneration in AD. Thus, we will demonstrate how intracellular trafficking is implicated in AD and unravel an important disease mechanism.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › neurobiology
• medical and health sciences › basic medicine › neurology › dementia › alzheimer
• natural sciences › biological sciences › biochemistry › biomolecules › proteins

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2012-CIG
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-CIG - Support for training and career development of researcher (CIG)

Koordinator

FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA

Kontakt Verwaltung

Ana Roberto (Mrs.)

• EU-Beitrag: € 100 000,00
• Adresse: CAMPO MARTIRES DA PATRIA 130 ; 1169 056 LISBOA ; Portugal
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten