Objective
As more people survive into old age, the prevalence of heart failure (HF), one of the most common and debilitating diseases in older people, will rise still further. Delaying or preventing HF will have great benefit to those at personal risk, their families, society and the economy. HOMAGE aims to provide a biomarker (BM) approach that will a) help identify i. patients at high risk of developing HF before the onset of symptoms and ii. subsets of patients who are more likely to respond to specifically targeted therapies (personalized medicine). In available cohorts, we will identify the most promising ‘omics-based BM profiles for the pre-symptomatic diagnosis and future prediction of HF in patients at risk. The predictive value of the BMs for other co-morbidities commonly associated with HF and ageing will also be investigated. Furthermore, in a prospective trial, we will investigate the potential for targeting preventive therapy at patients with the greatest likelihood of response and the lowest risk of adverse effects. Our selection of innovative ‘omics-based BMs is based on knowledge of biological pathways of the disease, which may facilitate identification of ‘Biotargets’ for future therapies. On the economic side, HOMAGE will act as an economic catalyst for European SMEs in the field of cardiovascular and ageing BMs, estimated to peak annual turnovers of up to 800 M€.
Fields of science
Topic(s)
Call for proposal
FP7-HEALTH-2012-INNOVATION-1
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Funding Scheme
CP-IP - Large-scale integrating projectCoordinator
75654 Paris
France
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Participants (21)
75015 PARIS
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21850 St Apollinaire
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1105 AZ AMSTERDAM
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BT29 4QY Crumlin
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8010 Graz
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M13 9PL Manchester
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31008 Pamplona
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4 Dublin
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HU6 7RX Hull
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6200 MD Maastricht
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20156 Milano
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30625 Hannover
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3000 Leuven
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WC1E 7HT London
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30322 Atlanta
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G12 8QQ Glasgow
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30659 Hannover
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12201 Albany Ny
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ST5 5BG Keele
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412 51 GOTEBORG
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10117 Berlin
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