The dendritic cell receptor DNGR-1: Modulation of endosomal dynamics upon recognition of necrotic cells

Projektinformationen

DNGR-1 in DCs

ID Finanzhilfevereinbarung: 329729

Projekt abgeschlossen

Startdatum 1 Mai 2013

Enddatum 30 April 2015

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 221 606,40

EU-Beitrag € 221 606,40

Koordiniert durch

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

Ziel

Dendritic cells (DCs) play an essential function in initiating adaptive immunity. Key to DC function are receptors for recognizing and capturing pathogens and damaged cells and for controlling subsequent antigen extraction, processing and presentation. DNGR-1 (also known as CLEC9A) is a DC-restricted C-type lectin receptor (CLR) that recognizes the actin cytoskeleton exposed on necrotic cells. DNGR-1 is not required for internalization of cell corpses by DCs but regulates their subsequent ability to crosspresent corpse-associated antigens to CD8+ T-cells. The mechanisms underlying DNGR-1 function are unknown but require receptor signaling upon ligand engagement and are though to relate to modulation of endocytic traffic. Here, I hypothesize DNGR-1 promotes the stabilization of a non-degradative endo-/phagosomal compartment containing dead-cell associated cargo to permit antigen extraction from cell corpses and subsequent crosspresentation. I propose to address this hypothesis by investigating the intracellular trafficking of DNGR-1 and its ligand and the role of DNGR-1 on the endo-/phagosomal environment in DCs.

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2012-IEF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

THE FRANCIS CRICK INSTITUTE LIMITED

Kontakt Verwaltung

Heather Joanne Woods (Ms.)

• EU-Beitrag: € 221 606,40
• Adresse: 1 MIDLAND ROAD ; NW1 1AT London ; Vereinigtes Königreich
• Region: London › Inner London — West › Camden and City of London
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten

Beteiligte (1)

CANCER RESEARCH UK LBG

Beteiligung beendet

Vereinigtes Königreich

Kontakt Verwaltung

Holly Elphinstone (Ms.)

• EU-Beitrag: Keine Daten
• Adresse: 2 Redman Place ; E20 1JQ LONDON
• Region: London › Inner London — West › Camden and City of London
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten