Objective
Healthy functionality in the brain relies on intricate neuron-glia networks. Recent data suggest that glial, including astrocytes, play a crucial role in the processing and storing on by the brain. In particular, synapses might not be bipartite, but rather tripartite structures, comprised of the pre- and the postsynaptic terminals and the surrounding astrocyte. Moreover, astrocytes, like neurons, form intricate interconnected networks that afford long-range communication via the propagation of calcium waves. Therefore, neurons and astrocytes form intertwined neuron-glial networks supporting active partnership between the two cell populations. Hence, understanding the nature of neuron-glia interactions is essential to understand how the brain functions, and will serve as a stepping stone for deciphering brain disorders.
Our long-term goal is to reveal the mechanisms that control and regulates the activity of combined neuron-glia networks. The specific objectives of this application, which are fundamental in the pursuit of that goal, are (1) to determine the properties of astrocytic modulation of synaptic transmission; and (2) to characterize how such modulation shapes neuronal activity in neuron-glia networks of the brain.
To pursue these aims we will employ a comprehensive theoretical investigation to develop mathematical and biophysical models in support to experiments, at the many levels and scales of action of neuron-astrocyte signaling.
The significance of understanding glia-neuron interactions is several-fold as it pertains to a very wide range of applications, from basic understanding of neuronal activity, to developing therapeutic strategies toward the treatment of neurological disorders. Here, we will focus on how modulations of synaptic transmission by astrocytes could favor the emergence of synchronized neuronal, leveraging the predictions of our theoretical approach in the perspective of brain disorders, and epilepsy in particular.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology epilepsy
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IOF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
78153 Le Chesnay Cedex
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.