Objectif The tumor microenvironment determines many of the hallmarks of cancer. Stromal components and malignant cells dialogue and mutually change their functional responses. Tumor infiltrating lymphocytes (TILs) are a prominent feature of solid tumors, whose presence has correlation with a better survival in cancer-patients. However TILs are severely restrained in their ability to tackle tumors as a result of immunosuppressive mechanisms. This proposal is based on the hypothesis that low levels of oxygen availability in solid tumors induce profound changes on the adaptative immune response mediated by HIF-1α and HIF-2α transcription factors. Research objectives include: 1) To study TILs behaviour under hypoxia 2) To explore the molecular mechanisms underlying the observed changes, and importantly, 3) To evaluate the impact of these changes for different immunotherapeutic strategies (monoclonal antibodies, adoptive transfers, and drugs targeting the hypoxia pathway).The state-of-the-art technical approaches to address these objectives include cutting-edge two-photon in vivo imaging to study the immune response inside hypoxic tumors, and unique-in-the-world transgenic mice to unravel the HIF-1α and HIF-2α pathway importance in T cells.This project will enable a more rational design of anti-tumor immunotherapies and could help to explain disease recurrence and identify potential targets for therapeutic interventions. Champ scientifique medical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineimmunologyimmunotherapy Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Appel à propositions FP7-PEOPLE-2012-IEF Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Contribution de l’UE € 221 606,40 Adresse TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge Royaume-Uni Voir sur la carte Région East of England East Anglia Cambridgeshire CC Type d’activité Higher or Secondary Education Establishments Contact administratif Renata Schaeffer (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée