Objetivo Though of tremendous benefit, the overuse of antibiotics has lead to the emergence of antibiotic resistance and may cause adverse events that impact on patient healthcare. Current diagnostic tools for facilitating the appropriate use of antibiotics in patients are inadequate.We will establish a broad-based strategy (not limited to a particular antibiotic group) that can be implemented on a broad scale to increase the effectiveness of antimicrobial therapy, reduce adverse events, and help limit the emergence of antimicrobial resistance in children and adults.At the heart of the TAILORED-Treatment project is a prospective clinical study in which we will recruit 1200 patients (>2000 patient samples) presenting with respiratory tract infections and/or sepsis. Patient cohorts will include equal representation of genders, children and adults. State-of-the-art molecular technologies will be applied to characterize host-pathogen interactions at the genomic, transcriptomic, proteomic and clinical level, resulting in a large-scale and unique multi-dimensional dataset. The consortium partners will develop new computational tools to interrogate this data, in order to provide new insights into personalized host-pathogen interactions, including the discovery of novel biomarkers for physicians to use in patient diagnosis and disease monitoring.Concurrently, using this data, we will construct a predictive personalized treatment algorithm that will lead to informed and personalized antimicrobial treatment regimens (indication, dosage, and duration) that are tailored to the needs (type of infection, presence of novel biomarkers etc) of children and adults presenting with respiratory infections and sepsis.This unique multi-dimensional dataset and personalized predictive treatment algorithm will be built into an easily navigable web-based, free-to-use, decision support system for use by physicians to explore and assist in patient-tailored antimicrobial treatment decisions. Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibioticsmedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2013.2.3.1-2 - Stratified approaches to antibacterial and/or antifungal treatment Convocatoria de propuestas FP7-HEALTH-2013-INNOVATION-1 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Aportación de la UE € 1 438 430,00 Dirección DR MOLEWATERPLEIN 40 3015 GD Rotterdam Países Bajos Ver en el mapa Región West-Nederland Zuid-Holland Groot-Rijnmond Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo John Hays (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (6) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo IBEXPERTS Ltd. Israel Aportación de la UE € 257 000,00 Dirección HAALON STREET 16A 43572 RAANANA Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Racheli Kreisberg (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITAIR MEDISCH CENTRUM UTRECHT Países Bajos Aportación de la UE € 729 987,00 Dirección HEIDELBERGLAAN 100 3584 CX Utrecht Ver en el mapa Región West-Nederland Utrecht Utrecht Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Louis Bont (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos HADASSAH MEDICAL ORGANIZATION Israel Aportación de la UE € 496 381,40 Dirección N/A 91120 Jerusalem Ver en el mapa Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Dan Engelhard (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos MEMED DIAGNOSTICS LTD Israel Aportación de la UE € 1 512 452,80 Dirección NAHUM HETH STREET 5 39120 TIRAT CARMEL Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Eran Eden (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos GOETEBORGS UNIVERSITET Suecia Aportación de la UE € 1 012 720,00 Dirección VASAPARKEN 405 30 Goeteborg Ver en el mapa Región Södra Sverige Västsverige Västra Götalands län Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Ellen Rydberg (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos NORAY BIOINFORMATICS SL España Aportación de la UE € 528 411,80 Dirección PARQUE TECNOLOGICO 801A 48160 DERIO Ver en el mapa Región Noreste País Vasco Bizkaia Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Eva González (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos