Objective The major bottleneck for plant biomass processing is fiber saccharification: the conversion of cell wall lignocellulosic biomass into fermentable sugars (en route to production of value-added chemicals like second generation biofuels). Some microbes enhance this step by using natural self-assembling proteinaceous nanocatalists known as cellulosomes. CellulosomePlus targets rational design of optimized cellulosomes to overcome this problem.This would allow efficient production of biofuels from low-value raw materials like inedible parts of plants and industrial residues (which are all renewable, sustainable and inexpensive). First we propose to characterize the physicochemical and structural properties (including mechanostability) as well as interactions of enzymes and scaffolds from natural cellulosomes and non-cellulosomal components. In parallel, we will characterize a suitable residual substrate from municipal waste (organic fraction of municipal solid waste) and develop improved assays to reliably follow cellulosomal enzymatic activity. The acquired knowledge will be complemented with rapid computational modelling at the atomic and supramolecular levels for testing and predictions. Experimental and theoretical knowledge will be then integrated to design improved cellulosomes (with high-selectivity, activity and cost-effectiveness). Further improvement will be obtained by iteration using high throughput screening of components. The improved cellulosomes generated through this innovative multidisciplinary approach represent a step towards green chemistry since they are biodegradable proteinaceous materials and therefore by-products and/or wastes are minimized due to the high enzymatic selectivity. Finally, the production of the optimized cellulosomes (and the process involved) will be scaled up to preindustrial scale to demonstrate their viable commercial production. These results will be patented and a roadmap will be drawn up towards future standardization. Fields of science engineering and technologyindustrial biotechnologybiomaterialsbiofuelsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesagricultural sciencesagricultural biotechnologybiomass Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2013.1.1-2 - Self-assembly of naturally occurring nanosystems Call for proposal FP7-NMP-2013-SMALL-7 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS EU contribution € 1 174 727,00 Address CALLE SERRANO 117 28006 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Ana Maria De La Fuente (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution € 513 290,00 Address HERZL STREET 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Gaby Bernstein (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution € 411 498,80 Address GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Hermann E Gaub (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTYTUT FIZYKI POLSKIEJ AKADEMII NAUK Poland EU contribution € 369 200,00 Address AL LOTNIKOW 32/46 02 668 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Activity type Research Organisations Administrative Contact Marek Cieplak (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 454 266,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Emilie Floch (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF LIMERICK Ireland EU contribution € 347 479,20 Address NATIONAL TECHNOLOGICAL PARK, PLASSEY - Limerick See on map Region Ireland Northern and Western Border Activity type Higher or Secondary Education Establishments Administrative Contact Sandra Hammersley (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DESIGNER ENERGY LTD Participation ended Israel EU contribution € 279 518,40 Address BERGMAN 2 76705 REHOVOT See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alon Karpol (Mr.) Links Contact the organisation Opens in new window Total cost No data ABENGOA BIOENERGIA NUEVAS TECNOLOGIAS SA Participation ended Spain EU contribution € 94 475,63 Address CAMPUS PALMAS ALTAS CALLE ENERGIA SOLAR 1 41014 SEVILLA See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marina Aguiar (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOPOLIS SL Spain EU contribution € 259 185,97 Address CALLE CATEDRATICO AGUSTIN ESCARDINO BENLLOCH 9 PARQUE CIENTIFICO DE LA UNIVERSIDAD DE VALENCIA 46980 PATERNA VALENCIA See on map Region Este Comunitat Valenciana Valencia/València Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Iryna Sukhotska (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CELDEZYNER LTD Israel EU contribution € 93 378,00 Address 2AD BERGMAN ST. 7670504 REHOVOT See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alon Karpol (Dr.) Links Contact the organisation Opens in new window Total cost No data