Objective In situ tissue engineering using a biodegradable synthetic scaffold that recruits endogenous cells from the bloodstream is emerging as a promising technology to create living heart valves inside the human body having the potential to last a life-time: one valve for life. Compared to classical tissue engineered heart valves this new technology demonstrates off-the-shelf availability at substantially reduced cost. The current proposal aims to further develop the synthetic biomaterials needed for the in situ tissue engineering of heart valves, to process these materials into a functional heart valve scaffold, and to perform all the necessary pre-clinical experiments to enable first-in-man clinical application. A novel approach to the biodegradable scaffold will be developed, that combines a relatively slowly degrading (months) elastomeric material with a fast degrading (weeks) bioactive hydrogel material. These materials will be processed into a fibrous heart valve scaffold by means of electrospinning. The elastomeric material ensure long term functionality of the valve while supporting in-vivo mature tissue formation, while the fast eroding hydrogel material controls the early inflammatory response and creates the necessary void space between the elastomeric fibers. A minimally invasive, transapical, implantation technique will be used for the placement of the heart valve scaffold at the aortic position, following our recent results. For this purpose, tailor-made stents will be developed. Fields of science engineering and technologymaterials engineeringfibersmedical and health sciencesmedical biotechnologytissue engineeringengineering and technologyindustrial biotechnologybiomaterials Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2013.2.2-1 - Biomaterials for Advanced Therapies and Medical Devices in the neurological/neuromuscular or cardiovascular fields Call for proposal FP7-NMP-2013-SME-7 See other projects for this call Funding Scheme CP-TP - Collaborative Project targeted to a special group (such as SMEs) Coordinator TECHNISCHE UNIVERSITEIT EINDHOVEN EU contribution € 1 440 313,00 Address GROENE LOPER 3 5612 AE Eindhoven Netherlands See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Higher or Secondary Education Establishments Administrative Contact Leon Luwijs (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all SUPRAPOLIX BV Netherlands EU contribution € 763 800,00 Address HORSTEN 1 MMP 1.29 5612 AX Eindhoven See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Anton Bosman (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT ZURICH Switzerland EU contribution € 1 451 404,00 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Simon Philipp Hoerstrup (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JENAVALVE TECHNOLOGY GMBH Participation ended Germany EU contribution € 51 291,43 Address GUERICKESTRASSE 25 80805 MUNCHEN BAYERN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Martin Schlun (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDICUT STENT TECHNOLOGY GMBH Germany EU contribution € 823 080,00 Address WILHELM BECKER STRASSE 11A 75179 PFORZHEIM See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christian Herzog (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data APPLETREE CI GROUP AG Switzerland EU contribution € 314 292,00 Address RUDOLF DIESEL STRASSE 3 8404 WINTERTHUR See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rubén Ibáñez (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data XELTIS BV Netherlands EU contribution € 807 952,57 Address DE LISMORTEL 31 R2 06 CAT BUILD 5612 AR Eindhoven See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Martijn Cox (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data