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Intelligent materials for in-situ heart Valve tissue engineering

Objective

In situ tissue engineering using a biodegradable synthetic scaffold that recruits endogenous cells from the bloodstream is emerging as a promising technology to create living heart valves inside the human body having the potential to last a life-time: one valve for life. Compared to classical tissue engineered heart valves this new technology demonstrates off-the-shelf availability at substantially reduced cost. The current proposal aims to further develop the synthetic biomaterials needed for the in situ tissue engineering of heart valves, to process these materials into a functional heart valve scaffold, and to perform all the necessary pre-clinical experiments to enable first-in-man clinical application. A novel approach to the biodegradable scaffold will be developed, that combines a relatively slowly degrading (months) elastomeric material with a fast degrading (weeks) bioactive hydrogel material. These materials will be processed into a fibrous heart valve scaffold by means of electrospinning. The elastomeric material ensure long term functionality of the valve while supporting in-vivo mature tissue formation, while the fast eroding hydrogel material controls the early inflammatory response and creates the necessary void space between the elastomeric fibers. A minimally invasive, transapical, implantation technique will be used for the placement of the heart valve scaffold at the aortic position, following our recent results. For this purpose, tailor-made stents will be developed.

Call for proposal

FP7-NMP-2013-SME-7
See other projects for this call

Coordinator

TECHNISCHE UNIVERSITEIT EINDHOVEN
Address
Groene Loper 3
5612 AE Eindhoven
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 440 313

Participants (6)

SUPRAPOLIX BV
Netherlands
EU contribution
€ 763 800
Address
Horsten 1 Mmp 1.29
5612 AX Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
University of Zurich
Switzerland
EU contribution
€ 1 451 404
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
JENAVALVE TECHNOLOGY GMBH

Participation ended

Germany
EU contribution
€ 51 291,43
Address
Guerickestrasse 25
80805 Munchen Bayern
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDICUT STENT TECHNOLOGY GMBH
Germany
EU contribution
€ 823 080
Address
Wilhelm Becker Strasse 11A
75179 Pforzheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
APPLETREE CI GROUP AG
Switzerland
EU contribution
€ 314 292
Address
Rudolf Diesel Strasse 3
8404 Winterthur
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
XELTIS BV
Netherlands
EU contribution
€ 807 952,57
Address
De Lismortel R2 06 Cat Build 31
5612 AR Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)