Objective CARODEL aims to valorise the results from the previous FP7 COLORSPORE project, in which initial isolation and characterization work was performed on Bacillus strains producing gastric-stable carotenoids. As the stability in the gastrointestinal tract (GIT), antioxidant activity and bioavailability of particular Bacillus carotenoids was shown to be higher than those of common dietary carotenoids, the conclusions from COLORSPORE provided strong and compelling reasons to support further development and commercialisation of these bacteria-derived carotenoids.CARODEL will therefore focus on the development of an efficient oral delivery strategy of such highly active carotenoids, in combination with evaluation of potential direct health-beneficial (probiotic) activity of the Bacillus delivery vehicle, with the ultimate aim to improve biomarkers associated with (the prevention of) cardiovascular disease (CVD). The relevance of using carotenoids for CVD prevention was recently shown by a positive EFSA opinion on the use of tomato lycopene for maintenance of a healthy blood flow.In practice, effective delivery of the carotenoids to the human body will be compared upon administration as i) vegetative Bacillus cells, ii) Bacillus spores or iii) extracted carotenoids. In parallel, the ability of the Bacillus strain to exert bona fide effects (i.e. effects on the host microbiota, metabolism and immunity) will be investigated using in vitro gut models and in vivo rat studies. Based on this, the best delivery strategy will be selected and validated in a human study, in which carotenoid bioavailability will be validated as well as endpoints related to CVD biomarkers and potential probiotic activity. In combination with a full safety assessment, a proof-of-concept production strategy and development of a business plan, the scientific evidence compiled in this project will provide a framework for efficient further commercialisation of a well-documented Bacillus carotenoid product Fields of science medical and health sciencesclinical medicinecardiologycardiovascular diseasesnatural sciencesbiological sciencesmicrobiology Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Topic(s) KBBE.2013.2.6-01 - Exploitation of results of Framework Programme projects in food, health and well-being by small and medium-sized enterprises Call for proposal FP7-KBBE-2013-7-single-stage See other projects for this call Funding Scheme CP-TP - Collaborative Project targeted to a special group (such as SMEs) Coordinator PRODIGEST EU contribution € 648 771,20 Address Technologiepark 3 9052 Gent zwijnaarde Belgium See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Sam Possemiers (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all SPOREGEN LIMITED United Kingdom EU contribution € 312 868,80 Address The london bioscience innovation centre 2 royal college street NW1 0NH London See on map Region London Inner London — West Camden and City of London Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Simon Cutting (Prof.) Links Contact the organisation Opens in new window Total cost No data BIOACTOR BV Netherlands EU contribution € 304 311,20 Address Oxfordlaan 70 6229 EV Maastricht See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Hans Van Der Saag (Mr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Italy EU contribution € 188 938,00 Address Corso umberto i, 40 80138 Napoli See on map Region Sud Campania Napoli Activity type Higher or Secondary Education Establishments Administrative Contact Ezio Ricca (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NORMEC OWS Belgium EU contribution € 83 533,00 Address Pantserschipstraat 163 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Steven De Meester (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France EU contribution € 191 358,40 Address 147 rue de l'universite 75007 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Sylvie Modeste (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT GENT Belgium EU contribution € 112 432,40 Address Sint pietersnieuwstraat 25 9000 Gent See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Higher or Secondary Education Establishments Administrative Contact Evelien Vandevelde (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOPOLIS SL Spain EU contribution € 154 610,00 Address Calle catedratico agustin escardino benlloch 9 parque cientifico de la universidad de valencia 46980 Paterna valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Iryna Sukhotska (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data