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Use of Microorganisms for Carotenoids Delivery: Next Generation of Probiotics for Cardiovascular Disease

Objective

CARODEL aims to valorise the results from the previous FP7 COLORSPORE project, in which initial isolation and characterization work was performed on Bacillus strains producing gastric-stable carotenoids. As the stability in the gastrointestinal tract (GIT), antioxidant activity and bioavailability of particular Bacillus carotenoids was shown to be higher than those of common dietary carotenoids, the conclusions from COLORSPORE provided strong and compelling reasons to support further development and commercialisation of these bacteria-derived carotenoids.
CARODEL will therefore focus on the development of an efficient oral delivery strategy of such highly active carotenoids, in combination with evaluation of potential direct health-beneficial (probiotic) activity of the Bacillus delivery vehicle, with the ultimate aim to improve biomarkers associated with (the prevention of) cardiovascular disease (CVD). The relevance of using carotenoids for CVD prevention was recently shown by a positive EFSA opinion on the use of tomato lycopene for maintenance of a healthy blood flow.
In practice, effective delivery of the carotenoids to the human body will be compared upon administration as i) vegetative Bacillus cells, ii) Bacillus spores or iii) extracted carotenoids. In parallel, the ability of the Bacillus strain to exert bona fide effects (i.e., effects on the host microbiota, metabolism and immunity) will be investigated using in vitro gut models and in vivo rat studies. Based on this, the best delivery strategy will be selected and validated in a human study, in which carotenoid bioavailability will be validated as well as endpoints related to CVD biomarkers and potential probiotic activity. In combination with a full safety assessment, a proof-of-concept production strategy and development of a business plan, the scientific evidence compiled in this project will provide a framework for efficient further commercialisation of a well-documented Bacillus carotenoid product

Field of science

  • /social sciences/economics and business

Call for proposal

FP7-KBBE-2013-7-single-stage
See other projects for this call

Funding Scheme

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinator

PRODIGEST
Address
Technologiepark 3
9052 Gent Zwijnaarde
Belgium
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 648 771,20
Administrative Contact
Sam Possemiers (Dr.)

Participants (7)

SPOREGEN LIMITED
United Kingdom
EU contribution
€ 312 868,80
Address
Queens Road 3 Westley Gate
RG1 4AP Reading Berkshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Cutting (Prof.)
BIOACTOR BV
Netherlands
EU contribution
€ 304 311,20
Address
Oxfordlaan 70
6229 EV Maastricht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hans Van Der Saag (Mr.)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
EU contribution
€ 188 938
Address
Corso Umberto I, 40
80138 Napoli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ezio Ricca (Prof.)
ORGANIC WASTE SYSTEMS NV
Belgium
EU contribution
€ 83 533
Address
Dok Noord 5
9000 Gent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Steven De Meester (Mr.)
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 191 358,40
Address
Rue De L'universite 147
75338 Paris Cedex 07
Activity type
Research Organisations
Administrative Contact
Sylvie Modeste (Mrs.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 112 432,40
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Evelien Vandevelde (Ms.)
BIOPOLIS SL
Spain
EU contribution
€ 154 610
Address
Calle Catedratico Agustin Escardino 9
46980 Paterna Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Iryna Sukhotska (Ms.)