Objective
Introns are non-coding intervals that interrupt the coding
sequences of eukaryotic genes. Intron removal is performed
by a complicated molecular machinery, called the
spliceosome, concomitantly with gene transcription. Introns
and the splicing machinery (or at least their traces) are
found in every sequenced eukaryotic genome. Moreover, many
introns are found at homologous positions across different
kingdoms, suggesting that some originate in the earliest
eukaryotes.
Introns are largely devoid of function, yet in humans (and
mammals in general), they make up more than~40% of the
genome. The most obvious evolutionary advantage of the
interrupted coding sequences is that they increase
functional complexity by enabling alternate assemblies.
Introns provide a powerful source of variations for natural
selection in many other ways, since splicing is tightly
coupled with transcription and export from the nucleus, and
intronic sequences frequently harbor regulatory elements.
The proposed project aims at developing bioinformatics tools
and mathematical models that help understanding randomness
and natural selection that shape exon-intron architecture in
different eukaryotic lineages. In particular, we will
investigate intron turnover in fast-evolving genes,
selective constraints on intron length and mechanisms of
intron gain on a large scale, using annotated whole genomes.
In addition to providing new insights into the ways
evolution affects gene structure, the developed
methods will be useful to produce better annotations of
coding regions and functional intronic elements.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences zoology mammalogy
- natural sciences mathematics applied mathematics mathematical model
- natural sciences biological sciences genetics genomes eukaryotic genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6726 Szeged
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.