Obiettivo Hematopoieic stem cells (HSCs) are characterized by their ability to self-renew and differentiate into cells of all hematopoietic lineages. During steady-state, HSCs are mostly quiescent and responsible for normal hematopoietic differentiation. In cases of stress such as infection or injury, HSCs need to be activated and repair the hematopoeitic system in a regenerative response that involves synchronous and hierarchical replacement of the hematopoietic lineages. Multiple signaling pathways constantly specify a complex network of stimuli that HSCs need to decode and act on. Rapid recovery after injury is crucial for patients receiving myeloablative treatments, or suffering from a hematologic malignancy. It is therefore important to understand how signaling pathways control HSC responses during normal hematopoietic differentiation and stress induced regeneration. Our goal is to use zebrafish genetics and genome-wide techniques to understand how signaling pathways synergize and integrate with the internal hematopoietic program and control normal hematopoietic differentiation and stress-induced regeneration. Ultimately our approach may reveal new players of hematopoietic regeneration that can be exploited therapeutically. Campo scientifico natural sciencesbiological sciencesgeneticsmedical and health sciencesmedical biotechnologycells technologiesstem cells Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2013-CIG - Marie-Curie Action: "Career Integration Grants" Invito a presentare proposte FP7-PEOPLE-2013-CIG Vedi altri progetti per questo bando Meccanismo di finanziamento MC-CIG - Support for training and career development of researcher (CIG) Coordinatore MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Contributo UE € 100 000,00 Indirizzo HOFGARTENSTRASSE 8 80539 Munchen Germania Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Research Organisations Contatto amministrativo Vanessa Holzer (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
