Role of Nrf2 transcription factor in diabetic vasculopathy, oxidative stress and inflammation

Project Information

NRFDIABVASC

Grant agreement ID: 224861

Project closed

Start date 1 June 2008

End date 31 July 2009

Funded under

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Total cost € 29 166,67

EU contribution € 29 166,67

Coordinated by

UNIVERSIDAD AUTONOMA DE MADRID
Spain

Objective

Vascular diseases represent the main cause of disability and mortality linked with long-term diabetes mellitus, a metabolic disease affecting around 20% of total world population. Diabetic vessels undergo both functional and structural changes, rendering them prone to cardiovascular pathology, including atherosclerosis, hypertension or myocardial infarction. Hyperglycemia, together with inflammation, play a key role by altering cell metabolism and different signal transduction pathways in vascular cells. These mechanisms share a net increase of reactive oxygen species (ROS) in the vasculature. The present proposal will focus on the role of an impaired balance of ROS and the antioxidant cellular defences and the key biological role of the Nrf2 transcription factor. The working hypothesis is that Nrf2 signaling play a critical role in the vasculature by contributing to maintenance of vascular homeostasis and protecting vascular dysfunction upon hyperglycemia and pro-inflammatory signals as occurs in diabetes. To this aim, we will address the essential role of Nrf2 in antioxidant gene expression and cell fate upon glucose and pro-inflammatory cytokines treatment in vascular cells, and determine vascular reactivity of an altered expression of antioxidant stress proteins in a model of type 1 diabetes in Nrf2 knockout mice. Taken together, the completion of this proposal will establish the biological significance of depletion of antioxidant genes and its consequence in the diabetic vasculature in a Nrf2 knockout mice type 1 model of diabetes.

Fields of science

• medical and health sciences › clinical medicine › angiology › vascular diseases
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases › arteriosclerosis
• medical and health sciences › clinical medicine › endocrinology › diabetes
• medical and health sciences › basic medicine › pathology
• medical and health sciences › basic medicine › physiology › homeostasis

Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Topic(s)

• PEOPLE-2007-4-3.IRG - Marie Curie Action: "International Reintegration Grants"

Call for proposal

FP7-PEOPLE-2007-4-3-IRG
See other projects for this call

Funding Scheme

MC-IRG - International Re-integration Grants (IRG)

Coordinator

UNIVERSIDAD AUTONOMA DE MADRID

• EU contribution: € 29 166,67
• Address: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO ; 28049 Madrid ; Spain
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Mª Carmen Puerta (Ms.)
• Total cost: No data