Objective
Vascular diseases represent the main cause of disability and mortality linked with long-term diabetes mellitus, a metabolic disease affecting around 20% of total world population. Diabetic vessels undergo both functional and structural changes, rendering them prone to cardiovascular pathology, including atherosclerosis, hypertension or myocardial infarction. Hyperglycemia, together with inflammation, play a key role by altering cell metabolism and different signal transduction pathways in vascular cells. These mechanisms share a net increase of reactive oxygen species (ROS) in the vasculature. The present proposal will focus on the role of an impaired balance of ROS and the antioxidant cellular defences and the key biological role of the Nrf2 transcription factor. The working hypothesis is that Nrf2 signaling play a critical role in the vasculature by contributing to maintenance of vascular homeostasis and protecting vascular dysfunction upon hyperglycemia and pro-inflammatory signals as occurs in diabetes. To this aim, we will address the essential role of Nrf2 in antioxidant gene expression and cell fate upon glucose and pro-inflammatory cytokines treatment in vascular cells, and determine vascular reactivity of an altered expression of antioxidant stress proteins in a model of type 1 diabetes in Nrf2 knockout mice. Taken together, the completion of this proposal will establish the biological significance of depletion of antioxidant genes and its consequence in the diabetic vasculature in a Nrf2 knockout mice type 1 model of diabetes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2007-4-3-IRG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
28049 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.