ECMEDProject ID: 642881
The Extracellular Matrix in Epileptogenesis
Total cost:EUR 3 047 025,60
EU contribution:EUR 3 047 025,60
Coordinated in:United Kingdom
Call for proposal:H2020-MSCA-ITN-2014See other projects for this call
Funding scheme:MSCA-ITN-ETN - European Training Networks
Over 50 million people worldwide have epilepsy and 30% are resistant to our present therapies. Epilepsy, therefore, comprises a major burden to society and so there is a pressing need for new approaches to treatment. The brain extracellular matrix (ECM) plays a critical role in governing brain excitability and function. Although research into the role of the ECM in neuronal signalling and network function has advanced considerably in recent years, its full translational potential has yet to be realised. There is growing evidence for a major role of the ECM in epilepsy including the association between ECM protein mutations and epilepsy, changes in the ECM and associated proteins during the development of epilepsy and the strong association between the ECM and brain diseases associated with epilepsy including stroke, traumatic brain injury, neurodegeneration and autism.
This proposal brings together considerable expertise from academic and industry partners in the biology of the ECM with experts in epilepsy research. This, therefore, represents a truly collaborative effort to determine not only the role of the ECM in the development of epilepsy but also novel approaches to treat and to prevent epilepsy.
The academic partners will focus on specific research questions, whilst the industrial members will provide diagnostic, treatment and advanced research tools. The project has a strong translational theme and the combination of basic and translational science will be of great benefit for the training of young researchers.
Trainees will be exposed to courses, workshops, joint research meetings and inter-laboratory visits. The focus of the training programme is on expanding knowledge and the application of such knowledge to address pertinent question relevant to the diagnosis, prognosis and treatment of epilepsy, so providing an ideal insight into translational neuroscience.
EU contribution: EUR 273 287,88
WC1E 6BT LONDON
EU contribution: EUR 516 122,64
VIA MOREGO 30
EU contribution: EUR 498 432,96
SIGMUND FREUD STRASSE 27
EU contribution: EUR 269 145,36
YLIOPISTONRANTA 1 E
EU contribution: EUR 249 216,48
EU contribution: EUR 224 137,44
UL. LUDWIKA PASTEURA 3
02 093 WARSZAWA
EU contribution: EUR 250 560
EU contribution: EUR 255 374,28
EU contribution: EUR 247 872,96
CALLE BALDIRI REIXAC 10
EU contribution: EUR 262 875,60
Boulevard Charles Livon 58