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The Extracellular Matrix in Epileptogenesis

Objective

Over 50 million people worldwide have epilepsy and 30% are resistant to our present therapies. Epilepsy, therefore, comprises a major burden to society and so there is a pressing need for new approaches to treatment. The brain extracellular matrix (ECM) plays a critical role in governing brain excitability and function. Although research into the role of the ECM in neuronal signalling and network function has advanced considerably in recent years, its full translational potential has yet to be realised. There is growing evidence for a major role of the ECM in epilepsy including the association between ECM protein mutations and epilepsy, changes in the ECM and associated proteins during the development of epilepsy and the strong association between the ECM and brain diseases associated with epilepsy including stroke, traumatic brain injury, neurodegeneration and autism.
This proposal brings together considerable expertise from academic and industry partners in the biology of the ECM with experts in epilepsy research. This, therefore, represents a truly collaborative effort to determine not only the role of the ECM in the development of epilepsy but also novel approaches to treat and to prevent epilepsy.
The academic partners will focus on specific research questions, whilst the industrial members will provide diagnostic, treatment and advanced research tools. The project has a strong translational theme and the combination of basic and translational science will be of great benefit for the training of young researchers.
Trainees will be exposed to courses, workshops, joint research meetings and inter-laboratory visits. The focus of the training programme is on expanding knowledge and the application of such knowledge to address pertinent question relevant to the diagnosis, prognosis and treatment of epilepsy, so providing an ideal insight into translational neuroscience.

Field of science

  • /medical and health sciences/basic medicine/neurology/stroke
  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /medical and health sciences/basic medicine/neurology/epilepsy
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/neurobiology
  • /natural sciences/biological sciences/neurobiology/neuroscience

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITY COLLEGE LONDON
Address
Gower Street
WC1E 6BT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 273 287,88

Participants (10)

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
EU contribution
€ 516 122,64
Address
Via Morego 30
16163 Genova
Activity type
Research Organisations
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
Germany
EU contribution
€ 498 432,96
Address
Sigmund Freud Strasse 27
53127 Bonn
Activity type
Research Organisations
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 269 145,36
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE
Germany
EU contribution
€ 249 216,48
Address
Brenneckestrasse 6
39118 Magdeburg
Activity type
Research Organisations
INSTYTUT BIOLOGII DOSWIADCZALNEJ IM. M. NENCKIEGO POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 224 137,44
Address
Ul. Ludwika Pasteura 3
02 093 Warszawa
Activity type
Research Organisations
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 250 560
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Participation ended

Netherlands
EU contribution
€ 0
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
IPROTEOS SL
Spain
EU contribution
€ 247 872,96
Address
Calle Baldiri Reixac 10
08028 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 262 875,60
Address
Boulevard Charles Livon 58
13284 Marseille
Activity type
Higher or Secondary Education Establishments
AMC MEDICAL RESEARCH BV
Netherlands
EU contribution
€ 255 374,28
Address
Meibergdreef 9
1105AZ Amsterdam Zuidoost
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)