CARDISProject ID: 644798
Early stage CARdio Vascular Disease Detection with Integrated Silicon Photonics
Early identification of individuals at risk for CVD allows early intervention to halt or reverse the pathological process. This is the driver of Medtronic and partners to develop a mobile, low-cost, non-invasive, point-of-care screening device for CVD.
Assessment of arterial stiffness by measurement of the aortic pulse wave velocity (aPWV) is included in the latest ESC/ESH guidelines for CVD risk prediction. Besides aPWV, early identification of arterial stenosis and cardiac contraction abnormalities can be used to improve CVD risk classification. However, no tools are available today to screen a large population at primary care on these parameters, and individuals that are considered to be at low or moderate risk are too often undiagnosed.
The objective of CARDIS is to investigate and demonstrate the concept of a mobile, low-cost device based on a silicon photonics integrated laser Doppler vibrometer and validate the concept for the screening of arterial stiffness, detection of stenosis and heart failure. We will:
•Investigate, design and fabricate the optical subsystems and components: silicon photonics chip with integrated Ge-detectors, micro-optics, micro-optical laser bench, optical package
•Integrate the subsystems and build a multi-array laser interferometer system
•Develop a process flow scalable to high volumes for all sub-systems and their integration steps
•Investigate and develop the biomechanical model to translate optical signals related to skin-level vibrations into underlying CVD physiological events
•Validate the system in a clinical setting
Photonics integration is needed to enable a device that is mobile (small size, small weight, robust (no moving parts), low cost (high volume scalable process flow) and allows fast screening (laser array).
The partners commit to protect IP whenever possible, disseminate results via open access and, if target specs are met, commercially exploit and transfer the technology to create social and economic impact.
EU contribution: EUR 721 413
EU contribution: EUR 602 990
EU contribution: EUR 662 750
AM VOGELHERD 46
EU contribution: EUR 426 579
EU contribution: EUR 399 500
SINT PIETERSNIEUWSTRAAT 25
EU contribution: EUR 215 000
101 Rue de Tolbiac
EU contribution: EUR 274 059
MILE END ROAD
E1 4NS LONDON
EU contribution: EUR 176 915
6200 MD MAASTRICHT
EU contribution: EUR 150 000