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Early stage CARdio Vascular Disease Detection with Integrated Silicon Photonics

Objective

Early identification of individuals at risk for CVD allows early intervention to halt or reverse the pathological process. This is the driver of Medtronic and partners to develop a mobile, low-cost, non-invasive, point-of-care screening device for CVD.

Assessment of arterial stiffness by measurement of the aortic pulse wave velocity (aPWV) is included in the latest ESC/ESH guidelines for CVD risk prediction. Besides aPWV, early identification of arterial stenosis and cardiac contraction abnormalities can be used to improve CVD risk classification. However, no tools are available today to screen a large population at primary care on these parameters, and individuals that are considered to be at low or moderate risk are too often undiagnosed.

The objective of CARDIS is to investigate and demonstrate the concept of a mobile, low-cost device based on a silicon photonics integrated laser Doppler vibrometer and validate the concept for the screening of arterial stiffness, detection of stenosis and heart failure. We will:
•Investigate, design and fabricate the optical subsystems and components: silicon photonics chip with integrated Ge-detectors, micro-optics, micro-optical laser bench, optical package
•Integrate the subsystems and build a multi-array laser interferometer system
•Develop a process flow scalable to high volumes for all sub-systems and their integration steps
•Investigate and develop the biomechanical model to translate optical signals related to skin-level vibrations into underlying CVD physiological events
•Validate the system in a clinical setting

Photonics integration is needed to enable a device that is mobile (small size, small weight, robust (no moving parts), low cost (high volume scalable process flow) and allows fast screening (laser array).

The partners commit to protect IP whenever possible, disseminate results via open access and, if target specs are met, commercially exploit and transfer the technology to create social and economic impact.

Call for proposal

H2020-ICT-2014-1
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Coordinator

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Address
Kapeldreef 75
3001 Leuven
Belgium
Activity type
Research Organisations
EU contribution
€ 721 413

Participants (8)

MEDTRONIC BAKKEN RESEARCH CENTER B.V.
Netherlands
EU contribution
€ 602 990
Address
Endepolsdomein 5
6229GW Maastricht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SIOS MESSTECHNIK
Germany
EU contribution
€ 662 750
Address
Am Vogelherd 46
98693 Ilmenau
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
EU contribution
€ 426 579
Address
Western Road
T12 YN60 Cork
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT GENT
Belgium
EU contribution
€ 399 500
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 215 000
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 274 059
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 176 915
Address
Minderbroedersberg 4
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
FUNDICO BVBA
Belgium
EU contribution
€ 150 000
Address
Gruuthuselaan 19
8020 Oostkamp
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)