Objective
The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2+ ion; it is expressed almost ubiquitously; interacts with multiple Gα subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling.
The objectives of CaSR Biomedicine are:
1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective.
2. Elucidate ligand- and tissue-dependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general;
3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders.
4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area.
Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciencesclinical medicinepneumologyasthma
- medical and health sciencesbasic medicineneurologydementiaalzheimer
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health sciencesclinical medicineoncologybreast cancer
- medical and health sciencesclinical medicineoncologycolorectal cancer
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Programme(s)
Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
1090 Wien
Austria
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Participants (12)
CF24 0DE Cardiff
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08950 Esplugues De Llobregat
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1165 Kobenhavn
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L69 7ZX Liverpool
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M13 9PL Manchester
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50121 Florence
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OX1 2JD Oxford
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80025 Amiens
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1081 HV Amsterdam
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2100 Goedoello
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
10136 TORINO
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1020 Wien
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partners (5)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
8020 Graz
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Budapest
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
4056 Basel
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Wien
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
59120 Loos
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.