The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2+ ion; it is expressed almost ubiquitously; interacts with multiple Gα subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling.
The objectives of CaSR Biomedicine are:
1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective.
2. Elucidate ligand- and tissue-dependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general;
3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders.
4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area.
Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).
Field of science
- /medical and health sciences/clinical medicine/cancer/colorectal cancer
- /medical and health sciences/clinical medicine/endocrinology/diabetes
- /medical and health sciences/clinical medicine/pneumology/asthma
- /social sciences/educational sciences
- /natural sciences/biological sciences/biochemistry/biomolecules/proteins
- /medical and health sciences/medical biotechnology/cells technologies/stem cells
- /medical and health sciences/basic medicine/neurology/alzheimer
- /medical and health sciences/clinical medicine/nephrology/kidney diseases
- /medical and health sciences/clinical medicine/cancer/breast cancer
- /natural sciences/mathematics/applied mathematics/mathematical model
- /natural sciences/computer and information sciences/artificial intelligence/computational intelligence
- /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases
- /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
- /natural sciences/biological sciences/neurobiology
Call for proposal
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Funding SchemeMSCA-ITN-ETN - European Training Networks