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Calcium-Sensing Receptor (CaSR): Therapeutics for Non-Communicable Diseases

Objective

The calcium sensing receptor (CaSR) is a class C Gprotein-coupled receptor that plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary Ca excretion. Abnormal CaSR function is implicated in calciotropic disorders, and in non-calciotropic disorders such as Alzheimer’s disease (AD), cardiovascular disease (CVD), diabetes (DM), sarcopenia and cancer, which account for >25% of the global disease burden. The CaSR is a unique GPCR whose principal physiological ligand is the Ca2+ ion; it is expressed almost ubiquitously; interacts with multiple Gα subtypes regulating highly divergent downstream signalling pathways, depending on the cellular context. The CaSR Biomedicine is a fully translational project that utilises the concept of a single molecule, the CaSR, influencing a range of physiological and disease processes, to develop a unique, strong multidisciplinary and intersectoral scientific training programme preparing 14 young scientists to become specialists in GPCR biology and signalling.
The objectives of CaSR Biomedicine are:
1. Educate and train Early Stage Researchers to become highly innovative scientists to enhance their career perspective.
2. Elucidate ligand- and tissue-dependent differences in CaSR physiology by examining its functions at cellular level and thus to contribute to the understanding of GPCR signalling in general;
3. Assess how CaSR function is altered in AD, CVD, DM, sarcopenia, and cancer, and to find innovative CaSR-based therapeutic approaches for these major, age-related disorders.
4. Establish long-lasting interdisciplinary and intersectoral cooperation among researchers and between researchers and industry, to strengthen the European Research Area.
Therefore the CaSR Biomedicine will investigate the complexity of CaSR signalling and function to identify CaSR-based therapeutic approaches to diseases linked to changes in CaSR expression or function (AD, CVD, DM, sarcopenia, and cancer).

Coordinator

MEDIZINISCHE UNIVERSITAET WIEN
Net EU contribution
€ 511 868,16
Address
Spitalgasse 23
1090 Wien
Austria

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Other funding
€ 511 868,16

Participants (12)

CARDIFF UNIVERSITY
United Kingdom
Net EU contribution
€ 273 287,88
Address
Newport Road 30 36
CF24 0DE Cardiff

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Region
Wales East Wales Cardiff and Vale of Glamorgan
Activity type
Higher or Secondary Education Establishments
Other funding
€ 273 287,88
FUNDACIO PRIVADA PER A LA RECERCA I LA DOCENCIA SANT JOAN DE DEU
Spain
Net EU contribution
€ 247 872,96
Address
Santa Rosa 39-4
08950 Esplugues De Llobregat

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 247 872,96
KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 290 081,88
Address
Norregade 10
1165 Kobenhavn

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Region
Danmark Hovedstaden Byen København
Activity type
Higher or Secondary Education Establishments
Other funding
€ 290 081,88
THE UNIVERSITY OF LIVERPOOL
United Kingdom
Net EU contribution
€ 273 287,88
Address
Brownlow Hill 765 Foundation Building
L69 7ZX Liverpool

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Region
North West (England) Merseyside Liverpool
Activity type
Higher or Secondary Education Establishments
Other funding
€ 273 287,88
THE UNIVERSITY OF MANCHESTER
United Kingdom
Net EU contribution
€ 273 287,88
Address
Oxford Road
M13 9PL Manchester

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Region
North West (England) Greater Manchester Manchester
Activity type
Higher or Secondary Education Establishments
Other funding
€ 273 287,88
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
Net EU contribution
€ 258 061,32
Address
Piazza San Marco 4
50121 Florence

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Region
Centro (IT) Toscana Firenze
Activity type
Higher or Secondary Education Establishments
Other funding
€ 258 061,32
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 273 287,88
Address
Wellington Square University Offices
OX1 2JD Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Other funding
€ 273 287,88
UNIVERSITE DE PICARDIE JULES VERNE
France
Net EU contribution
€ 262 875,60
Address
Chemin Du Thil
80025 Amiens

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Region
Hauts-de-France Picardie Somme
Activity type
Higher or Secondary Education Establishments
Other funding
€ 262 875,60
STICHTING VU
Netherlands
Net EU contribution
€ 255 374,28
Address
De Boelelaan 1105
1081 HV Amsterdam

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Other funding
€ 255 374,28
BIOTALENTUM TUDASFEJLESZTO KFT
Hungary
Net EU contribution
€ 223 913,52
Address
Aulich Lajos Utca 26
2100 Goedoello

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Közép-Magyarország Pest Pest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 223 913,52
S.A.F.AN. BIOINFORMATICS - SAS DI PUGLIESE LUISA
Italy
Net EU contribution
€ 258 061,32
Address
Via Fulvio Croce 23/b
10136 Torino

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Ovest Piemonte Torino
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 258 061,32
TISSUEGNOSTICS GMBH
Austria
Net EU contribution
€ 255 934,08
Address
Taborstrasse 10/2
1020 Vienna

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Wien Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 255 934,08

Partners (5)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

FH JOANNEUM GESELLSCHAFT MBH
Austria
Net EU contribution
€ 0,00
Address
Alte Poststrasse 149
8020 Graz

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Region
Südösterreich Steiermark Graz
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

AHT-Management
Hungary
Net EU contribution
€ 0,00
Address

Budapest

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

NOVARTIS PHARMA AG
Switzerland
Net EU contribution
€ 0,00
Address
Lichtstrasse 35
4056 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Amgen GmbH
Austria
Net EU contribution
€ 0,00
Address

Wien

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

IMABIOTECH SAS
France
Net EU contribution
€ 0,00
Address
152 Rue Du Docteur Yersin
59120 Loos

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Hauts-de-France Nord-Pas de Calais Nord
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00