Objective Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families. Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke recovery and patients quality of life. RESSTORE European multicentre randomised phase IIb will explore, for the first time, the efficacy (functional recovery) and safety of intravenous infusion of allogenic adipose tissue derived mesenchymal stem cells (ADMSCs) in 400 stroke patients. Therapeutic effects of ADMSCs will be assessed and monitored in patients using clinical rating scales, multimodal MRI and novel blood biomarkers. Additionally, the societal value and cost-effectiveness of ADMSCs-based regenerative therapy will be evaluated through health economics and predictive in silico simulations. Complementary ancillary animal studies will support the clinical trial by defining i) if the treatment response can be further enhanced by intensive rehabilitation, ii) the contribution of co-morbidities and iii) the mechanism(s) underlying the therapeutic effect.The European regenerative therapy capacities (France, Spain, Finland, United Kingdom and Czech Republic), developed in RESSTORE will cover the full value chain in the field (large scale GMP cell production, clinical testing, biomarkers discovery, understanding of the restoring mechanisms, modelling, biobanking, economic studies, exploitation and communication plan). RESSTORE will thus surely contribute, together with the workforce trained in the context of the programme, to improve its public and private (SME) competitiveness and increase the attractiveness of Europe as a reference location to develop and clinically assess new innovative therapeutic options for brain diseases. Fields of science medical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesclinical medicinephysiotherapymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesbasic medicineneurologystrokesocial scienceseconomics and businesseconomicshealth economics Keywords Regenerative Medicine Stroke Cell Therapy Stem Cell Allogenic Adipose Tissue Derived Mesenchymal Stem Cells Recovery Brain repair In Silico Health Economics Multimodal MRI Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.3. - Treating and managing disease Topic(s) PHC-15-2015 - Clinical research on regenerative medicine Call for proposal H2020-PHC-2014-2015 See other projects for this call Sub call H2020-PHC-2015-single-stage_RTD Funding Scheme RIA - Research and Innovation action Coordinator UNIVERSITE GRENOBLE ALPES Net EU contribution € 1 781 937,50 Address 621 avenue centrale 38058 Grenoble France See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Isère Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 781 937,50 Participants (28) Sort alphabetically Sort by Net EU contribution Expand all Collapse all SERVICIO MADRILENO DE SALUD Spain Net EU contribution € 134 600,00 Address Paseo de la castellana, 280 28046 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 134 600,00 CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE France Net EU contribution € 182 700,00 Address Boulevard de la chantourne 38700 La tronche See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Isère Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 182 700,00 FAKULTNI NEMOCNICE U SV ANNY V BRNE Czechia Net EU contribution € 20 000,00 Address Pekarska 53 602 00 Brno See on map Region Česko Jihovýchod Jihomoravský kraj Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 20 000,00 SERVICIO ANDALUZ DE SALUD Spain Net EU contribution € 446 825,00 Address Avenida de la constitucion 18 41071 Sevilla See on map Region Sur Andalucía Sevilla Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 446 825,00 UNIVERSITY OF GLASGOW United Kingdom Net EU contribution € 20 000,00 Address University avenue G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 20 000,00 ITA-SUOMEN YLIOPISTO Finland Net EU contribution € 185 035,00 Address Yliopistonranta 8 70211 Kuopio See on map Region Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 185 035,00 ETABLISSEMENT FRANCAIS DU SANG France Net EU contribution € 799 718,00 Address Avenue du stade de france 20 93210 La plaine saint denis See on map Region Ile-de-France Ile-de-France Seine-Saint-Denis Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 799 718,75 TAMPEREEN KORKEAKOULUSAATIO SR Finland Net EU contribution € 360 791,00 Address Kalevantie 4 33100 Tampere See on map Region Manner-Suomi Länsi-Suomi Pirkanmaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 360 791,25 HISTOCELL SL Spain Net EU contribution € 327 365,00 Address Parque tecnologico de bizkaia edificio 801 piso 2 48160 Derio bizkaia See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Noreste País Vasco Bizkaia Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 327 365,00 OY MEDFILES LTD Finland Net EU contribution € 802 187,50 Address Volttikatu 5 70700 Kuopio See on map Region Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 802 187,50 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France Net EU contribution € 130 325,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 130 325,00 FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA Spain Net EU contribution € 350 000,00 Address Passeig vall d hebron 119-129 edificio de recerca 08035 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 350 000,00 HOSPICES CIVILS DE LYON France Net EU contribution € 70 000,00 Address Quai des celestins 3 69002 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 70 000,00 ASSOCIATION GROUPE ESSEC France Net EU contribution € 200 000,00 Address Avenue bernard hirsch 95021 Cergy pontoise cedex See on map Region Ile-de-France Ile-de-France Val-d’Oise Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 200 000,00 NOVADISCOVERY France Net EU contribution € 274 375,00 Address 1 place giovanni da verrazzano 69009 Lyon See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 274 375,00 FINOVATIS France Net EU contribution € 232 000,00 Address 62 rue de bonnel 69003 Lyon See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 232 000,00 CENTRE HOSPITALIER UNIVERSITAIRE DEBESANCON France Net EU contribution € 1 700,00 Address 3 bd alexandre fleming 25030 Besancon cedex See on map Region Bourgogne-Franche-Comté Franche-Comté Doubs Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France Net EU contribution € 1 700,00 Address 55 boulevard diderot 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE France Net EU contribution € 1 700,00 Address Rue viguerie 2 hotel dieu saint jacques 31052 Toulouse cedex 3 See on map Region Occitanie Midi-Pyrénées Haute-Garonne Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 CHU HOPITAUX DE BORDEAUX France Net EU contribution € 1 700,00 Address Rue dubernat 12 33404 Talence See on map Region Nouvelle-Aquitaine Aquitaine Gironde Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 CHU COTE DE NACRE - CAEN France Net EU contribution € 1 700,00 Address Avenue de la cote de nacre 14033 Caen cedex 5 See on map Region Normandie Basse-Normandie Calvados Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 FUNDACION INSTITUTO DE ESTUDIOS DE CIENCIAS DE LA SALUD DE CASTILLA Y LEON Spain Net EU contribution € 1 700,00 Address Parque santa clara 42002 Soria See on map Region Centro (ES) Castilla y León Soria Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU FUNDACION Spain Net EU contribution € 1 700,00 Address C sant quinti 77-79 08041 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 SERVICIO DE SALUD DE CASTILLA LA MANCHA Spain Net EU contribution € 1 700,00 Address Avenida rio guadiana 4 45007 Toledo See on map Region Centro (ES) Castilla-La Mancha Toledo Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 SERVIZO GALEGO DE SAUDE Spain Net EU contribution € 1 700,00 Address Edificio administrativo san lázaro 15703 Santiago de compostela See on map Region Noroeste Galicia A Coruña Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE GIRONA DOCTOR JOSEP TRUETA Spain Net EU contribution € 1 700,00 Address Calle dr. castany sn edificio de la mancomunidad 2 parque hospitalario marti julia 17190 Girona See on map Region Este Cataluña Girona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 PIRKANMAA HOSPITAL DISTRICT Finland Net EU contribution € 1 700,00 Address Teiskontie 35 33521 Tampere See on map Region Manner-Suomi Länsi-Suomi Pirkanmaa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00 GROUPE HOSPITALIER UNIVERSITAIRE PARIS PSYCHIATRIE ET NEUROSCIENCES France Net EU contribution € 1 700,00 Address Rue cabanis 1 75014 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 700,00