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REgenerative Stem cell therapy for STroke in Europe

Objective

Stroke is the second leading cause of death in the world population. When not fatal, stroke often results in disability, due to motor and cognitive impairments, and secondary health problems affecting not only patients but also their families.
Building on emerging preclinical and pilot clinical evidences, RESSTORE will focus on the clinical assessment of regenerative cell therapy to improve stroke recovery and patients quality of life. RESSTORE European multicentre randomised phase IIb will explore, for the first time, the efficacy (functional recovery) and safety of intravenous infusion of allogenic adipose tissue derived mesenchymal stem cells (ADMSCs) in 400 stroke patients. Therapeutic effects of ADMSCs will be assessed and monitored in patients using clinical rating scales, multimodal MRI and novel blood biomarkers. Additionally, the societal value and cost-effectiveness of ADMSCs-based regenerative therapy will be evaluated through health economics and predictive in silico simulations. Complementary ancillary animal studies will support the clinical trial by defining i) if the treatment response can be further enhanced by intensive rehabilitation, ii) the contribution of co-morbidities and iii) the mechanism(s) underlying the therapeutic effect.
The European regenerative therapy capacities (France, Spain, Finland, United Kingdom and Czech Republic), developed in RESSTORE will cover the full value chain in the field (large scale GMP cell production, clinical testing, biomarkers discovery, understanding of the restoring mechanisms, modelling, biobanking, economic studies, exploitation and communication plan). RESSTORE will thus surely contribute, together with the workforce trained in the context of the programme, to improve its public and private (SME) competitiveness and increase the attractiveness of Europe as a reference location to develop and clinically assess new innovative therapeutic options for brain diseases.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2015-single-stage_RTD

Coordinator

UNIVERSITE GRENOBLE ALPES
Net EU contribution
€ 1 781 937,50
Address
621 Avenue Centrale
38058 Grenoble
France

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (28)

SERVICIO MADRILENO DE SALUD
Spain
Net EU contribution
€ 134 600,00
Address
Plaza Carlos Trias Bertran 7
28020 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
CENTRE HOSPITALIER UNIVERSITAIRE DE GRENOBLE
France
Net EU contribution
€ 182 700,00
Address
Boulevard De La Chantourne
38700 La Tronche

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Isère
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
FAKULTNI NEMOCNICE U SV. ANNY V BRNE
Czechia
Net EU contribution
€ 20 000,00
Address
Pekarska 53
656 91 Brno

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Region
Jihovýchod Jihomoravský kraj
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
SERVICIO ANDALUZ DE SALUD
Spain
Net EU contribution
€ 446 825,00
Address
Avenida De La Constitucion 18
41071 Sevilla

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Region
Andalucía Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
UNIVERSITY OF GLASGOW
United Kingdom
Net EU contribution
€ 20 000,00
Address
University Avenue
G12 8QQ Glasgow

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Region
West Central Scotland Glasgow City
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ITA-SUOMEN YLIOPISTO
Finland
Net EU contribution
€ 185 035,00
Address
Yliopistonranta 1 E
70211 Kuopio

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
ETABLISSEMENT FRANCAIS DU SANG
France
Net EU contribution
€ 799 718,00
Address
Avenue Du Stade De France 20
93210 La Plaine Saint Denis

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Region
Ile-de-France Ile-de-France Seine-Saint-Denis
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,75
TAMPEREEN KORKEAKOULUSAATIO SR
Finland
Net EU contribution
€ 360 791,00
Address
Kalevantie 4
33100 Tampere

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Region
Manner-Suomi Länsi-Suomi Pirkanmaa
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,25
HISTOCELL SL
Spain
Net EU contribution
€ 327 365,00
Address
Parque Tecnologico De Bizkaia Edificio 801 Piso 2
48160 Derio Bizkaia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Noreste País Vasco Bizkaia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
OY MEDFILES LTD
Finland
Net EU contribution
€ 802 187,50
Address
Volttikatu 5
70700 Kuopio

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 130 325,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
Net EU contribution
€ 350 000,00
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00
HOSPICES CIVILS DE LYON
France
Net EU contribution
€ 70 000,00
Address
Quai Des Celestins 3
69002 Lyon

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Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
ASSOCIATION GROUPE ESSEC
France
Net EU contribution
€ 200 000,00
Address
Avenue Bernard Hirsch
95021 Cergy Pontoise Cedex

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Region
Ile-de-France Ile-de-France Val-d’Oise
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
NOVADISCOVERY
France
Net EU contribution
€ 274 375,00
Address
1 Place Giovanni Da Verrazzano
69009 Lyon

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
FINOVATIS
France
Net EU contribution
€ 232 000,00
Address
62 Rue De Bonnel
69003 Lyon

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Auvergne-Rhône-Alpes Rhône-Alpes Rhône
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00
CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON
France
Net EU contribution
€ 1 700,00
Address
Place Saint Jacques 2
25030 Besancon Cedex

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Region
Bourgogne-Franche-Comté Franche-Comté Doubs
Activity type
Research Organisations
Other funding
€ 0,00
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Net EU contribution
€ 1 700,00
Address
3 Avenue Victoria
75000 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 0,00
CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE
France
Net EU contribution
€ 1 700,00
Address
Rue Viguerie 2 Hotel Dieu Saint Jacques
31052 Toulouse Cedex 3

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Region
Occitanie Midi-Pyrénées Haute-Garonne
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
CHU HOPITAUX DE BORDEAUX
France
Net EU contribution
€ 1 700,00
Address
Rue Dubernat 12
33404 Talence

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Region
Nouvelle-Aquitaine Aquitaine Gironde
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
CHU COTE DE NACRE - CAEN
France
Net EU contribution
€ 1 700,00
Address
Avenue De La Cote De Nacre
14033 Caen Cedex 5

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Region
Normandie Basse-Normandie Calvados
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
FUNDACION INSTITUTO DE ESTUDIOS DE CIENCIAS DE LA SALUD DE CASTILLA Y LEON
Spain
Net EU contribution
€ 1 700,00
Address
Parque Santa Clara
42002 Soria

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Region
Castilla y León Soria
Activity type
Research Organisations
Other funding
€ 0,00
INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU FUNDACION
Spain
Net EU contribution
€ 1 700,00
Address
C Sant Quinti 77-79
08041 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 0,00
SERVICIO DE SALUD DE CASTILLA LA MANCHA
Spain
Net EU contribution
€ 1 700,00
Address
Avenida Rio Guadiana 4
45007 Toledo

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Region
Castilla-La Mancha Toledo
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
SERVIZO GALEGO DE SAUDE
Spain
Net EU contribution
€ 1 700,00
Address
Edificio Administrativo San Lázaro
15703 Santiago De Compostela

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Region
Galicia A Coruña
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE GIRONA DOCTOR JOSEP TRUETA
Spain
Net EU contribution
€ 1 700,00
Address
Calle Dr. Castany Sn Edificio De La Mancomunidad 2 Parque Hospitalario Marti Julia
17190 Girona

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Region
Este Cataluña Girona
Activity type
Research Organisations
Other funding
€ 0,00
PIRKANMAA HOSPITAL DISTRICT
Finland
Net EU contribution
€ 1 700,00
Address
Teiskontie 35
33521 Tampere

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Region
Manner-Suomi Länsi-Suomi Pirkanmaa
Activity type
Research Organisations
Other funding
€ 0,00
GROUPE HOSPITALIER UNIVERSITAIRE PARIS PSYCHIATRIE ET NEUROSCIENCES
France
Net EU contribution
€ 1 700,00
Address
Rue Cabanis 1
75014 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Other funding
€ 0,00