Objective
Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying cirrhotic liver diseases. The ChiLTERN project relates to topic PHC 18 ‘establishing effectiveness of health care interventions in the paediatric population’. The ChiLTERN project builds on a unique opportunity to undertake a comprehensive research programme linked to an ambitious global partnership which will see the single largest clinical trial (the Paediatric Hepatic International Tumour Trial - PHITT) ever undertaken in this population of patients, with several randomised questions in six subgroups of patients. ChiLTERN will allow us to move towards an era of personalised therapy in which each patient will receive the correct amount of chemotherapy and will undergo has the best surgical operation (surgical resection or liver transplant). By using both clinical and biological information, we can assign patients more accurately to risk groups based on their survival. Using genetic tests and biomarkers, we will determine those children who may be at risk of developing long term side effects (deafness, heart failure, kidney damage). In addition, biomarkers will allow us to monitor during therapy and detect toxicities early before serious damage is done so that we can adapt treatment and prevent these problems. Finally, we will be using imaging technology tools which will help our surgeons plan liver operations more safely and effectively. Ultimately ChiLTERN will allow us to cure more children with liver cancer, expose fewer children to toxic chemotherapy and ensure their surgery is both effective and safe.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
B15 2TT Birmingham
United Kingdom
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Participants (29)
40033 Casalecchio Di Reno Bo
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NE1 7RU Newcastle Upon Tyne
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1200 Bruxelles / Brussel
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Participation ended
35122 Padova
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3008 BERN
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41071 Sevilla
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
14004 Cordoba
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72074 Tuebingen
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
72076 Tuebingen
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80210 Gdansk
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80539 MUNCHEN
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53127 Bonn
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91000 Evry
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
35033 Rennes Cedex 9
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08916 Badalona Barcelona
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24118 Kiel
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0450 Oslo
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35128 Padova
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462 80 Vanersborg
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D08 HP97 Dublin
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150 06 Praha 5
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28359 BREMEN
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
35127 Padova
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3584CS Utrecht
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70029 Kys
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00165 Roma
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62098 Tel Aviv
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Participation ended
1090 Wien
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1090 Wien
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