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Children’s Liver Tumour European Research Network

Objective

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying cirrhotic liver diseases. The ChiLTERN project relates to topic PHC 18 ‘establishing effectiveness of health care interventions in the paediatric population’. The ChiLTERN project builds on a unique opportunity to undertake a comprehensive research programme linked to an ambitious global partnership which will see the single largest clinical trial (the Paediatric Hepatic International Tumour Trial - PHITT) ever undertaken in this population of patients, with several randomised questions in six subgroups of patients. ChiLTERN will allow us to move towards an era of personalised therapy in which each patient will receive the correct amount of chemotherapy and will undergo has the best surgical operation (surgical resection or liver transplant). By using both clinical and biological information, we can assign patients more accurately to risk groups based on their survival. Using genetic tests and biomarkers, we will determine those children who may be at risk of developing long term side effects (deafness, heart failure, kidney damage). In addition, biomarkers will allow us to monitor during therapy and detect toxicities early before serious damage is done so that we can adapt treatment and prevent these problems. Finally, we will be using imaging technology tools which will help our surgeons plan liver operations more safely and effectively. Ultimately ChiLTERN will allow us to cure more children with liver cancer, expose fewer children to toxic chemotherapy and ensure their surgery is both effective and safe.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2015-two-stage

Coordinator

THE UNIVERSITY OF BIRMINGHAM
Net EU contribution
€ 2 676 440,35
Address
Edgbaston
B15 2TT Birmingham
United Kingdom

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (29)

CINECA CONSORZIO INTERUNIVERSITARIO
Italy
Net EU contribution
€ 333 750,00
Address
Via Magnanelli 6/3
40033 Casalecchio Di Reno Bo

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Region
Nord-Est Emilia-Romagna Bologna
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Net EU contribution
€ 119 055,00
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne

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Region
North East (England) Northumberland and Tyne and Wear Tyneside
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CLINIQUE UNIVERSITAIRE SAINT-LUC ASBL
Belgium
Net EU contribution
€ 236 402,25
Address
Avenue Hippocrate 10
1200 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI PADOVA

Participation ended

Italy
Net EU contribution
€ 11 759,50
Address
Via 8 Febbraio 2
35122 Padova

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Region
Nord-Est Veneto Padova
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SCHWEIZERISCHE PADIATRISCHE ONKOLOGIE GRUPPE (SPOG)
Switzerland
Net EU contribution
€ 0,00
Address
Effingerstrasse 40
3008 Bern

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Region
Schweiz/Suisse/Svizzera Espace Mittelland Bern / Berne
Activity type
Other
Non-EU contribution
€ 250 000,00
SERVICIO ANDALUZ DE SALUD
Spain
Net EU contribution
€ 155 312,50
Address
Avenida De La Constitucion 18
41071 Sevilla

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Region
Andalucía Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FUNDACION PARA LA INVESTIGACION BIOMEDICA DE CORDOBA
Spain
Net EU contribution
€ 56 312,50
Address
Avenida Menendez Pidal Sn
14004 Cordoba

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Region
Andalucía Córdoba
Activity type
Research Organisations
Non-EU contribution
€ 0,00
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
Net EU contribution
€ 406 250,00
Address
Geschwister-scholl-platz
72074 Tuebingen

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Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

Universitaetsklinikum Tuebingen
Germany
Net EU contribution
€ 1 800,00
Address
Geissweg 3
72076 Tuebingen

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Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Research Organisations
Non-EU contribution
€ 0,00
GDANSKI UNIWERSYTET MEDYCZNY
Poland
Net EU contribution
€ 181 425,00
Address
Ulica M Sklodowskiej Curie 3a
80210 Gdansk

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Region
Makroregion północny Pomorskie Trójmiejski
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 762 250,00
Address
Geschwister Scholl Platz 1
80539 Muenchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITATSKLINIKUM BONN
Germany
Net EU contribution
€ 337 132,81
Address
Venusberg-campus 1
53127 Bonn

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Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
XENTECH SAS
France
Net EU contribution
€ 86 750,00
Address
Rue Pierre Fontaine 4
91000 Evry

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CENTRE HOSPITALIER UNIVERSITAIRE DE RENNES
France
Net EU contribution
€ 472 356,00
Address
Rue Henri Le Guilloux -Hopital 2
35033 Rennes Cedex 9

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Region
Bretagne Bretagne Ille-et-Vilaine
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
Net EU contribution
€ 1 209 548,09
Address
Ctra De Canyet S/n
08916 Badalona Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

Participation ended

Germany
Net EU contribution
€ 15 606,00
Address
Olshausenstrasse 40
24118 Kiel

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Region
Schleswig-Holstein Schleswig-Holstein Kiel, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
OSLO UNIVERSITETSSYKEHUS HF
Norway
Net EU contribution
€ 107 387,50
Address
Kirkeveien 166 Tarnbygget
0450 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AZIENDA OSPEDALE UNIVERSITA PADOVA
Italy
Net EU contribution
€ 170 875,00
Address
Via Nicolo Giustiniani 1
35128 Padova

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Region
Nord-Est Veneto Padova
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
VÄSTRA GÖTALANDSREGIONEN
Sweden
Net EU contribution
€ 117 825,00
Address
Regionens Hus
462 80 Vanersborg

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Region
Södra Sverige Västsverige Västra Götalands län
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
OUR LADYS CHILDRENS HOSPITAL CRUMLIN
Ireland
Net EU contribution
€ 92 262,50
Address
Crumlin
D12N512 Dublin

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Region
Ireland Eastern and Midland Dublin
Activity type
Other
Non-EU contribution
€ 0,00
FAKULTNI NEMOCNICE V MOTOLE
Czechia
Net EU contribution
€ 36 725,00
Address
V Uvalu 84
150 06 Praha 5

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Region
Praha Hlavní město Praha
Activity type
Research Organisations
Non-EU contribution
€ 0,00
MEVIS MEDICAL SOLUTIONS AG
Germany
Net EU contribution
€ 75 000,00
Address
Caroline-herschel-strasse 1
28359 Bremen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bremen Bremen Bremen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ISTITUTO DI RICERCA PEDIATRICA CITTA DELLA SPERANZA
Italy
Net EU contribution
€ 100 000,00
Address
Corso Stati Uniti 4
35127 Padova

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Region
Nord-Est Veneto Padova
Activity type
Other
Non-EU contribution
€ 0,00
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands
Net EU contribution
€ 48 000,00
Address
Heidelberglaan 25
3584CS Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Other
Non-EU contribution
€ 0,00
POHJOIS-SAVON SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
Net EU contribution
€ 20 000,00
Address
Pl 100
70029 Kys

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Savo
Activity type
Research Organisations
Non-EU contribution
€ 0,00
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
Net EU contribution
€ 71 365,00
Address
Piazza Sant Onofrio 4
00165 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CLALIT HEALTH SERVICES
Israel
Net EU contribution
€ 20 000,00
Address
Arlozorov Street 101
62098 Tel Aviv

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Activity type
Research Organisations
Non-EU contribution
€ 0,00
ST ANNA KINDERKREBSFORSCHUNG VEREIN

Participation ended

Austria
Net EU contribution
€ 0,00
Non-EU contribution
€ 0,00
ST. ANNA KINDERKREBSFORSCHUNG GMBH
Austria
Net EU contribution
€ 20 075,00
Address
Zimmermannplatz 10
1090 Wien

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Region
Wien Wien
Activity type
Research Organisations
Non-EU contribution
€ 0,00