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Children’s Liver Tumour European Research Network

Objective

Liver cancer in the paediatric population is rare with an incidence approximately 1-1.5 per million population. The commonest tumour seen in the childhood population is hepatoblastoma (HB), usually seen in young children and infants. Much rarer (about 10% of paediatric liver cancers) is hepatocellular carcinoma (HCC), usually seen in the teenage population and sometimes associated with underlying cirrhotic liver diseases. The ChiLTERN project relates to topic PHC 18 ‘establishing effectiveness of health care interventions in the paediatric population’. The ChiLTERN project builds on a unique opportunity to undertake a comprehensive research programme linked to an ambitious global partnership which will see the single largest clinical trial (the Paediatric Hepatic International Tumour Trial - PHITT) ever undertaken in this population of patients, with several randomised questions in six subgroups of patients. ChiLTERN will allow us to move towards an era of personalised therapy in which each patient will receive the correct amount of chemotherapy and will undergo has the best surgical operation (surgical resection or liver transplant). By using both clinical and biological information, we can assign patients more accurately to risk groups based on their survival. Using genetic tests and biomarkers, we will determine those children who may be at risk of developing long term side effects (deafness, heart failure, kidney damage). In addition, biomarkers will allow us to monitor during therapy and detect toxicities early before serious damage is done so that we can adapt treatment and prevent these problems. Finally, we will be using imaging technology tools which will help our surgeons plan liver operations more safely and effectively. Ultimately ChiLTERN will allow us to cure more children with liver cancer, expose fewer children to toxic chemotherapy and ensure their surgery is both effective and safe.

Field of science

  • /medical and health sciences/clinical medicine/surgery
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/liver cancer

Call for proposal

H2020-PHC-2015-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

THE UNIVERSITY OF BIRMINGHAM
Address
Edgbaston
B15 2TT Birmingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 938 971,25

Participants (24)

CINECA CONSORZIO INTERUNIVERSITARIO
Italy
EU contribution
€ 333 750
Address
Via Magnanelli 6/3
40033 Casalecchio Di Reno Bo
Activity type
Research Organisations
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 113 342,50
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
CLINIQUES UNIVERSITAIRES SAINT-LUC
Belgium
EU contribution
€ 236 402,25
Address
Avenue Hippocrate 10
1200 Bruxelles
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI PADOVA

Participation ended

Italy
EU contribution
€ 11 759,50
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
SCHWEIZERISCHE PADIATRISCHE ONKOLOGIE GRUPPE (SPOG)
Switzerland
EU contribution
€ 0
Address
Effingerstrasse 40
3008 Bern
Activity type
Other
SERVICIO ANDALUZ DE SALUD
Spain
EU contribution
€ 187 575
Address
Avenida De La Constitucion 18
41071 Sevilla
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 406 250
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
GDANSKI UNIWERSYTET MEDYCZNY
Poland
EU contribution
€ 181 425
Address
Ulica M Sklodowskiej Curie 3A
80210 Gdansk
Activity type
Higher or Secondary Education Establishments
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 702 250
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 230 500
Address
Venusberg-campus 1
53127 Bonn
Activity type
Higher or Secondary Education Establishments
XENTECH SAS
France
EU contribution
€ 56 250
Address
Rue Pierre Fontaine 4
91000 Evry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE HOSPITALIER UNIVERSITAIRE DE RENNES
France
EU contribution
€ 472 356
Address
Rue Henri Le Guilloux -Hopital 2
35033 Rennes Cedex 9
Activity type
Higher or Secondary Education Establishments
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
EU contribution
€ 1 109 518,50
Address
Ctra De Canyet S/n
08916 Badalona Barcelona
Activity type
Research Organisations
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 121 875
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU contribution
€ 107 387,50
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
AZIENDA OSPEDALE UNIVERSITA PADOVA
Italy
EU contribution
€ 170 875
Address
Via Nicolo Giustiniani 1
35128 Padova
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
VASTRA GOTALANDS LANS LANDSTING
Sweden
EU contribution
€ 117 825
Address
Regionens Hus
462 80 Vanersborg
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
OUR LADYS CHILDRENS HOSPITAL CRUMLIN
Ireland
EU contribution
€ 92 262,50
Address
Crumlin
D12N512 Dublin
Activity type
Other
FAKULTNI NEMOCNICE V MOTOLE
Czechia
EU contribution
€ 36 725
Address
V Uvalu 84
150 06 Praha 5
Activity type
Research Organisations
MEVIS MEDICAL SOLUTIONS AG
Germany
EU contribution
€ 75 000
Address
Caroline-herschel-strasse 1
28359 Bremen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISTITUTO DI RICERCA PEDIATRICA CITTA DELLA SPERANZA
Italy
EU contribution
€ 100 000
Address
Corso Stati Uniti 4
35127 Padova
Activity type
Other
PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV
Netherlands
EU contribution
€ 48 000
Address
Heidelberglaan 25
3584CS Utrecht
Activity type
Other
POHJOIS-SAVON SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
EU contribution
€ 20 000
Address
Pl 100
70029 Kys
Activity type
Research Organisations
OSPEDALE PEDIATRICO BAMBINO GESU
Italy
EU contribution
€ 71 365
Address
Piazza Sant Onofrio 4
00165 Roma
Activity type
Other