Objective
G protein-coupled receptors (GPCRs) are the largest family of cell surface signal transducing proteins encoded by the
human genome. They allow the cell to respond to diverse array of extracellular signals, control most (patho)physiological
processes, and are currently the therapeutic target of over 30% of marketed drugs. However, GPCR drug discovery is still
characterised by a very high attrition rate, which reflects our inadequate understanding of the complex mechanisms of
GPCR signalling and regulation.
Up until recently, understanding of GPCR function was obtained from snapshots of receptors at different points in time and a
major limitation for the study of GPCRs has been the inability to assess receptor activation and subsequent signalling events
with high temporal (duration and frequency) or spatial (location) resolution. However, in the recent years there has been an
explosion of biophysical and imaging approaches that will allow greater temporal and spatial resolution of receptor function
than ever before. In this project we will measure ligand binding, receptor conformational changes, G protein activation,
recruitment of regulatory proteins and receptor trafficking in real time and in live cells. We will therefore obtain detailed
mechanistic understanding of the dynamics of GPCR activity in health and in disease that will reveal novel intervention
points for future, more effective receptor-based therapies.
This proposal combines my expertise in the study of GPCR interacting proteins and their role in receptor signalling and
trafficking with the expertise of the Host Institution in the application of state-of-the-art imaging and biophysical approaches
to study of this receptor family. As such, this project will not only broaden my research and technical skills in GPCR
visualization, but it will also result in the establishment of a unique technological platform for the study of the dynamics of
GPCR function within the Host Institution.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2015
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
NG7 2RD Nottingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.