Objetivo Near-infrared (NIR) fluorescence molecular imaging is a supra-discipline that enables visualisation of cellular function and real-time tracking of molecular processes in living organisms without perturbing them. If exploited to its maximum potential, NIR-fluorescence could have hugely positive impact for early stage diagnosis of diseases such as cancer, neurological and cardiovascular disease, the optimisation of preclinical and clinical tests for new medication and act as a real-time guide during surgery. This proposal seeks support for a MSC Fellowship to develop new biologically responsive off to on switchable NIR fluorochromes i.e. NIR fluorescent probes that respond selectively to cellular uptake and with specificity for cancer cells achieved through bio-conjugation with proven targeting agents. Specifically, the focus is on the design, synthesis, photophysical characterisation, in vitro cell imaging and preliminary in vivo assessment of such probes for the ultimate in vivo detection of colorectal cancer metastasis. Colorectal cancer is the third most common cancer and remains a major public health issue in Europe because of its high prevalence, morbidity, and mortality. The synergetic combination of the host laboratory’s interdisciplinary expertise, the host institution’s ability to deliver a comprehensive training program and the applicant’s excellent prior Ph.D. training experience in developing fluorescence chromophores with function-tailored photophysical properties is the perfect match to deliver the project goals and provide the stepping stone to independent researcher for the applicant. Ámbito científico medical and health scienceshealth sciencespublic healthmedical and health sciencesclinical medicinesurgerymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesclinical medicineoncologycolorectal cancermedical and health sciencesclinical medicinecardiologycardiovascular diseases Programa(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Tema(s) MSCA-IF-2015-EF - Marie Skłodowska-Curie Individual Fellowships (IF-EF) Convocatoria de propuestas H2020-MSCA-IF-2015 Consulte otros proyectos de esta convocatoria Régimen de financiación MSCA-IF-EF-ST - Standard EF Coordinador ROYAL COLLEGE OF SURGEONS IN IRELAND Aportación neta de la UEn € 175 866,00 Dirección ST STEPHEN'S GREEN 123 2 Dublin Irlanda Ver en el mapa Región Ireland Northern and Western Border Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 175 866,00