Objective
Rationale
The inability of pre-clinical studies to predict clinical efficacy is a major bottleneck in drug development. In severe asthma this bottleneck results from: a lack of useful and validated biomarkers, underperforming pre-clinical models, inadequate and incomplete sub-phenotyping, and insufficient disease understanding.
Hypothesis
The use of biomarker profiles comprised of various types of high-dimensional data, integrated with an innovative systems biology approach into distinct phenotype handprints, will enable significantly better prediction of therapeutic efficacy than single or even clustered biomarkers of one data type and will identify novel targets.
Strategy
U-BIOPRED proposes a staged-strategy:
I)Generating an international consensus on diagnostic criteria for severe asthma.
II)Unbiased discovery of sub-phenotypes of severe asthma in adult and paediatric patient cohorts using biomarker profiles (“fingerprints”) and systems biology to define “phenotype/handprints”.
III)Validating the handprints for exacerbations, disease progression, and experimental challenges.
IV)Using the handprints to improve human/animal in vivo and ex vivo models.
V)Establishing the responsiveness and predictability of the handprints in gold standard and experimental therapeutic interventions.
VI)Refinement of the diagnostic criteria and definition of severe asthma sub-phenotypes by incorporating the handprints, thereby enabling more focused drug development and faster delivery proof of concept for novel drugs.
VII)Education, training and dissemination through a stakeholder platform and academic-industrial exchange, with potential for further growth as appropriate.
Innovative approach
We will use a novel systems biology approach to integrate high dimensional data from invasive, non-invasive and patient-reported outcomes. All studies will include academic and EFPIA partners as active contributors.
Fields of science
Call for proposal
IMI-JU-01-2008
See other projects for this call
Coordinator
NOVARTIS PHARMA AG
EU contribution
No data
Address
LICHTSTRASSE 35
4056 Basel
Switzerland
4056 Basel
Switzerland
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Region
Schweiz/Suisse/Svizzera
Nordwestschweiz
Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Thomas Martin (Dr)
Administrative Contact
Barbara Stolz (Dr)
Links
Total cost
No data
Participants (41)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 1 708 837,00
Address
MEIBERGDREEF 15
1105AZ Amsterdam
1105AZ Amsterdam
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Region
West-Nederland
Noord-Holland
Groot-Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rebecca Massonet (-)
Links
Total cost
No data
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 1 415 215,00
Address
Highfield
SO17 1BJ Southampton
SO17 1BJ Southampton
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Region
South East (England)
Hampshire and Isle of Wight
Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anna Kerhoas (Ms)
Links
Total cost
No data
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 1 110 668,00
Address
SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
SW7 2AZ LONDON
SW7 2AZ LONDON
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Region
London
Inner London — West
Westminster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Mrs)
Links
Total cost
No data
UNIVERSITA DEGLI STUDI DI CATANIA
Italy
EU contribution
€ 216 780,00
Address
PIAZZA UNIVERSITA 2
95131 Catania
95131 Catania
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Region
Isole
Sicilia
Catania
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Pia Aiello (-)
Links
Total cost
No data
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
EU contribution
€ 96 226,00
Address
VIA CRACOVIA 50
00133 Roma
00133 Roma
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Region
Centro (IT)
Lazio
Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nicola Blefari Melazzi (Prof)
Links
Total cost
No data
Hvidovre Hospital
Denmark
EU contribution
€ 7 060,00
Address
Kettegaard Alle
2650 Hvidovre
2650 Hvidovre
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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Jørgen Vestbo (Professor)
Links
Total cost
No data
UNIWERSYTET JAGIELLONSKI
Poland
EU contribution
€ 158 480,00
Address
UL GOLEBIA 24
31-007 Krakow
31-007 Krakow
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Region
Makroregion południowy
Małopolskie
Miasto Kraków
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katarzyna Gubernat (Ms)
Links
Total cost
No data
UNIVERSITAET BERN
Switzerland
EU contribution
€ 137 171,00
Address
HOCHSCHULSTRASSE 6
3012 Bern
3012 Bern
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Region
Schweiz/Suisse/Svizzera
Espace Mittelland
Bern / Berne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Geiser (Prof)
Links
Total cost
No data
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 84 197,00
Address
ULLOI UTCA 26
1085 Budapest
1085 Budapest
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Region
Közép-Magyarország
Budapest
Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gábor Pörzse (Dr)
Links
Total cost
No data
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 931 633,00
Address
OXFORD ROAD
M13 9PL Manchester
M13 9PL Manchester
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Region
North West (England)
Greater Manchester
Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Ms)
Links
Total cost
No data
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 189 274,00
Address
BOULEVARD CHARLES LIVON 58 LE PHARO
13284 Marseille
13284 Marseille
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Region
Provence-Alpes-Côte d’Azur
Provence-Alpes-Côte d’Azur
Bouches-du-Rhône
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Celine Damon (Miss)
Links
Total cost
No data
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
EU contribution
€ 587 555,00
Address
HANSASTRASSE 27C
80686 Munchen
80686 Munchen
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Region
Bayern
Oberbayern
München, Kreisfreie Stadt
Activity type
Research Organisations
Administrative Contact
Andrea Zeumann (Ms)
Links
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No data
UMEA UNIVERSITET
Sweden
EU contribution
€ 75 002,00
Address
UNIVERSITETOMRADET
901 87 Umea
901 87 Umea
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Region
Norra Sverige
Övre Norrland
Västerbottens län
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Higher or Secondary Education Establishments
Administrative Contact
Lars Weinehall (Professor)
Links
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No data
UNIVERSITEIT GENT
Belgium
EU contribution
€ 212 485,00
Address
SINT PIETERSNIEUWSTRAAT 25
9000 Gent
9000 Gent
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Region
Vlaams Gewest
Prov. Oost-Vlaanderen
Arr. Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Vandepitte (Ms)
Links
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No data
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 555 414,00
Address
RUE MICHEL ANGE 3
75794 Paris
75794 Paris
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Region
Ile-de-France
Ile-de-France
Paris
Activity type
Research Organisations
Administrative Contact
Pascaline TOUTOIS (Dr)
Links
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No data
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 133 403,00
Address
LARGO GEMELLI 1
20123 Milano
20123 Milano
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Region
Nord-Ovest
Lombardia
Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Filippo Leone (Mr)
Links
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No data
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 60 943,00
Address
NORREGADE 10
1165 Kobenhavn
1165 Kobenhavn
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Region
Danmark
Hovedstaden
Byen København
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Higher or Secondary Education Establishments
Administrative Contact
Hans Bisgaard (Prof)
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No data
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 778 783,00
Address
Nobels Vag 5
17177 Stockholm
17177 Stockholm
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Region
Östra Sverige
Stockholm
Stockholms län
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Per-Olof Larsson (Mr)
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No data
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 154 898,00
Address
University Park
NG7 2RD Nottingham
NG7 2RD Nottingham
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East Midlands (England)
Derbyshire and Nottinghamshire
Nottingham
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Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr)
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UNIVERSITETET I BERGEN
Norway
EU contribution
€ 63 767,00
Address
MUSEPLASSEN 1
5020 Bergen
5020 Bergen
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Region
Norge
Vestlandet
Vestland
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Siv Johnsen (Ms)
Links
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No data
Netherlands Asthma Foundation
Netherlands
EU contribution
€ 100 660,00
Address
Speelkamp
3831PE Leusden
3831PE Leusden
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Administrative Contact
Csilla Molnar (Ms)
Links
Total cost
No data
EUROPEAN LUNG FOUNDATION
United Kingdom
EU contribution
€ 118 660,00
Address
GLOSSOP ROAD 442
S10 2PX Sheffield
S10 2PX Sheffield
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Region
Yorkshire and the Humber
South Yorkshire
Sheffield
Activity type
Other
Administrative Contact
Philippa Danielle Powell (Dr)
Links
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No data
ASTHMA UK LBG
United Kingdom
EU contribution
€ 94 660,00
Address
18 MANSELL STREET
E1 8AA LONDON
E1 8AA LONDON
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Region
London
Inner London — East
Tower Hamlets
Activity type
Other
Administrative Contact
Martin Tyler (Mr)
Links
Total cost
No data
EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING
Sweden
EU contribution
€ 94 660,00
Address
RUE DU CONGRES 35
1000 Brussel
1000 Brussel
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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest
Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Administrative Contact
Susanna Palkonen (Ms)
Links
Total cost
No data
Lega ltaliana Anti Fumo
Italy
EU contribution
€ 80 260,00
Address
Viale Alcide De Gasperi
95127 Catania
95127 Catania
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Administrative Contact
Guido D'Ignoti (-)
Links
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No data
INTERNATIONAL PRIMARY CARE RESPIRATORY GROUP
United Kingdom
EU contribution
€ 94 660,00
Address
4TH FLOOR 115 GEORGE STREET
EH2 4JN Edinburgh
EH2 4JN Edinburgh
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Region
Scotland
Eastern Scotland
Edinburgh
Activity type
Research Organisations
Administrative Contact
Samantha Louw (Mrs)
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No data
PHILIPS ELECTRONICS NEDERLAND BV
Netherlands
EU contribution
No data
Address
HIGH TECH CAMPUS 52
5656 AG Eindhoven
5656 AG Eindhoven
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Region
Zuid-Nederland
Noord-Brabant
Zuidoost-Noord-Brabant
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Keur (Mr)
Links
Total cost
No data
Synairgen Research Ltd.
United Kingdom
EU contribution
€ 38 050,00
Address
MAILPOINT 810, LEVEL F, SOUTH BLOCK,SOUTHAMPTON GENERAL HOSPITAL, TREMONA ROAD
S0166YD SOUTHAMPTON
S0166YD SOUTHAMPTON
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Administrative Contact
John Ward (MR)
Links
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No data
CIRCASSIA AB
Sweden
EU contribution
€ 30 400,00
Address
HANSELLISGATAN 13
75450 UPPSALA
75450 UPPSALA
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Region
Östra Sverige
Östra Mellansverige
Uppsala län
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Colerus (Mr)
Links
Total cost
No data
BIOSCI CONSULTING BVBA
Belgium
EU contribution
€ 605 700,00
Address
WEG NAAR GENEUTH 95
3631 Maasmechelen
3631 Maasmechelen
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Region
Vlaams Gewest
Prov. Limburg (BE)
Arr. Tongeren
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Scott Wagers (MD)
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No data
ALMIRALL SA
Spain
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No data
Address
GENERAL MITRE 151
08022 Barcelona
08022 Barcelona
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Region
Este
Cataluña
Barcelona
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jorge Beleta (Dr)
Links
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No data
ASTRAZENECA AB
Sweden
EU contribution
No data
Address
Vastra Maelarhamnen
151 85 Sodertaelje
151 85 Sodertaelje
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Region
Östra Sverige
Stockholm
Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lars Larsson (Assoc Professor)
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No data
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
EU contribution
No data
Address
BINGER STRASSE
55218 Ingelheim
55218 Ingelheim
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Region
Nordrhein-Westfalen
Arnsberg
Siegen-Wittgenstein
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rolf Goeggel (Dr)
Links
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No data
CHIESI FARMACEUTICI SPA
Italy
EU contribution
No data
Address
Via Palermo 26/a
43122 Parma
43122 Parma
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Region
Nord-Est
Emilia-Romagna
Parma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roberta Montacchini (Mrs.)
Links
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No data
GLAXOSMITHKLINE RESEARCH & DEVELOPMENT LIMITED
United Kingdom
EU contribution
No data
Address
79 NEW OXFORD STREET,
WC1A 1DG LONDON
WC1A 1DG LONDON
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Region
London
Inner London — West
Camden and City of London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Elaine Alison Irving (Dr)
Links
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No data
PFIZER LIMITED
Participation ended
United Kingdom
EU contribution
No data
Address
RAMSGATE ROAD
CT13 9NJ Sandwich
CT13 9NJ Sandwich
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Region
South East (England)
Kent
East Kent
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olga Krylova (Dr)
Links
Total cost
No data
F. HOFFMANN-LA ROCHE AG
Switzerland
EU contribution
No data
Address
GRENZACHERSTRASSE 124
4070 Basel
4070 Basel
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Region
Schweiz/Suisse/Svizzera
Nordwestschweiz
Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rob England (-)
Links
Total cost
No data
UCB PHARMA SA
Belgium
EU contribution
No data
Address
ALLEE DE LA RECHERCHE 60
1070 Bruxelles / Brussel
1070 Bruxelles / Brussel
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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest
Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest
Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Dresse (Mr)
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No data
JANSSEN BIOLOGICS BV
Netherlands
EU contribution
No data
Address
Einsteinweg 101
2300AG Leiden
2300AG Leiden
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Region
West-Nederland
Zuid-Holland
Agglomeratie Leiden en Bollenstreek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hendrik Carel Meijerink (Mr)
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No data
AMGEN
Belgium
EU contribution
No data
Address
TELECOMLAAN 5-7
1831 Diegem
1831 Diegem
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Region
Vlaams Gewest
Prov. Vlaams-Brabant
Arr. Halle-Vilvoorde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Gibbs (Mr.)
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No data
MERCK SHARP & DOHME CORP
United States
EU contribution
No data
Address
ONE MERCK DRIVE
08889 Whitehouse Station Nj
08889 Whitehouse Station Nj
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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Karen McGurk (Director)
Links
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No data