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Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes

Objective

Rationale
The inability of pre-clinical studies to predict clinical efficacy is a major bottleneck in drug development. In severe asthma this bottleneck results from: a lack of useful and validated biomarkers, underperforming pre-clinical models, inadequate and incomplete sub-phenotyping, and insufficient disease understanding.

Hypothesis
The use of biomarker profiles comprised of various types of high-dimensional data, integrated with an innovative systems biology approach into distinct phenotype handprints, will enable significantly better prediction of therapeutic efficacy than single or even clustered biomarkers of one data type and will identify novel targets.

Strategy
U-BIOPRED proposes a staged-strategy:
I)Generating an international consensus on diagnostic criteria for severe asthma.
II)Unbiased discovery of sub-phenotypes of severe asthma in adult and paediatric patient cohorts using biomarker profiles (“fingerprints”) and systems biology to define “phenotype/handprints”.
III)Validating the handprints for exacerbations, disease progression, and experimental challenges.
IV)Using the handprints to improve human/animal in vivo and ex vivo models.
V)Establishing the responsiveness and predictability of the handprints in gold standard and experimental therapeutic interventions.
VI)Refinement of the diagnostic criteria and definition of severe asthma sub-phenotypes by incorporating the handprints, thereby enabling more focused drug development and faster delivery proof of concept for novel drugs.
VII)Education, training and dissemination through a stakeholder platform and academic-industrial exchange, with potential for further growth as appropriate.

Innovative approach
We will use a novel systems biology approach to integrate high dimensional data from invasive, non-invasive and patient-reported outcomes. All studies will include academic and EFPIA partners as active contributors.

Call for proposal

IMI-JU-01-2008
See other projects for this call

Coordinator

NOVARTIS PHARMA AG
Address
Lichtstrasse 35
4056 Basel
Switzerland

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Principal investigator
Thomas Martin (Dr)
Administrative Contact
Barbara Stolz (Dr)

Participants (41)

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 1 708 837
Address
Meibergdreef 15
1105AZ Amsterdam

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rebecca Massonet (-)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 1 415 215
Address
Highfield
SO17 1BJ Southampton

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anna Kerhoas (Ms)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 1 110 668
Address
South Kensington Campus Exhibition Road
SW7 2AZ London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tatjana Palalic (Mrs)
UNIVERSITA DEGLI STUDI DI CATANIA
Italy
EU contribution
€ 216 780
Address
Piazza Universita 2
95131 Catania

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Pia Aiello (-)
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
EU contribution
€ 96 226
Address
Via Cracovia 50
00133 Roma

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nicola Blefari Melazzi (Prof)
Hvidovre Hospital
Denmark
EU contribution
€ 7 060
Address
Kettegaard Alle
2650 Hvidovre

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Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Jørgen Vestbo (Professor)
UNIWERSYTET JAGIELLONSKI
Poland
EU contribution
€ 158 480
Address
Ul. Golebia 24
31-007 Krakow

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katarzyna Gubernat (Ms)
UNIVERSITAET BERN
Switzerland
EU contribution
€ 137 171
Address
Hochschulstrasse 6
3012 Bern

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Geiser (Prof)
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 84 197
Address
Ulloi Utca 26
1085 Budapest

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gábor Pörzse (Dr)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 931 633
Address
Oxford Road
M13 9PL Manchester

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Ms)
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 189 274
Address
Boulevard Charles Livon 58 Le Pharo
13284 Marseille

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Celine Damon (Miss)
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
EU contribution
€ 587 555
Address
Hansastrasse 27c
80686 Munchen

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Activity type
Research Organisations
Administrative Contact
Andrea Zeumann (Ms)
UMEA UNIVERSITET
Sweden
EU contribution
€ 75 002
Address
Universitetomradet
901 87 Umea

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lars Weinehall (Professor)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 212 485
Address
Sint Pietersnieuwstraat 25
9000 Gent

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Vandepitte (Ms)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 555 414
Address
Rue Michel Ange 3
75794 Paris

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Activity type
Research Organisations
Administrative Contact
Pascaline TOUTOIS (Dr)
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 133 403
Address
Largo Gemelli 1
20123 Milano

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Filippo Leone (Mr)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 60 943
Address
Norregade 10
1165 Kobenhavn

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hans Bisgaard (Prof)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 778 783
Address
Nobels Vag 5
17177 Stockholm

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Per-Olof Larsson (Mr)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 154 898
Address
University Park
NG7 2RD Nottingham

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr)
UNIVERSITETET I BERGEN
Norway
EU contribution
€ 63 767
Address
Museplassen 1
5020 Bergen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Siv Johnsen (Ms)
Netherlands Asthma Foundation
Netherlands
EU contribution
€ 100 660
Address
Speelkamp
3831PE Leusden

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Administrative Contact
Csilla Molnar (Ms)
EUROPEAN LUNG FOUNDATION
United Kingdom
EU contribution
€ 118 660
Address
Glossop Road 442
S10 2PX Sheffield

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Activity type
Other
Administrative Contact
Philippa Danielle Powell (Dr)
ASTHMA UK LBG
United Kingdom
EU contribution
€ 94 660
Address
18 Mansell Street
E1 8AA London

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Activity type
Other
Administrative Contact
Martin Tyler (Mr)
EUROPEAN FEDERATION OF ASTHMA &ALLERGY ASSOCIATIONS IDEELL FORENING
Sweden
EU contribution
€ 94 660
Address
Rue Du Congres 35
1000 Bruxelles

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Activity type
Other
Administrative Contact
Susanna Palkonen (Ms)
Lega ltaliana Anti Fumo
Italy
EU contribution
€ 80 260
Address
Viale Alcide De Gasperi
95127 Catania

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Administrative Contact
Guido D'Ignoti (-)
INTERNATIONAL PRIMARY CARE RESPIRATORY GROUP
United Kingdom
EU contribution
€ 94 660
Address
4th Floor 115 George Street
EH2 4JN Edinburgh

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Activity type
Research Organisations
Administrative Contact
Samantha Louw (Mrs)
PHILIPS ELECTRONICS NEDERLAND BV
Netherlands
Address
High Tech Campus 52
5656 AG Eindhoven

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Keur (Mr)
Synairgen Research Ltd.
United Kingdom
EU contribution
€ 38 050
Address
Mailpoint 810, Level F, South Block,southampton General Hospital, Tremona Road
S0166YD Southampton

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Administrative Contact
John Ward (MR)
CIRCASSIA AB
Sweden
EU contribution
€ 30 400
Address
Hansellisgatan 13
75450 Uppsala

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Colerus (Mr)
BIOSCI CONSULTING BVBA
Belgium
EU contribution
€ 605 700
Address
Weg Naar Geneuth 95
3631 Maasmechelen

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Scott Wagers (MD)
ALMIRALL SA
Spain
Address
General Mitre 151
08022 Barcelona

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jorge Beleta (Dr)
ASTRAZENECA AB
Sweden
Address
Vastra Maelarhamnen
151 85 Sodertaelje

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lars Larsson (Assoc Professor)
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
Address
Binger Strasse
55218 Ingelheim

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rolf Goeggel (Dr)
CHIESI FARMACEUTICI SPA
Italy
Address
Via Palermo 26/a
43122 Parma

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roberta Montacchini (Mrs.)
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Address
Great West Road 980
TW89GS Brentford

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Elaine Alison Irving (Dr)
PFIZER LIMITED

Participation ended

United Kingdom
Address
Ramsgate Road
CT13 9NJ Sandwich

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Olga Krylova (Dr)
F. HOFFMANN-LA ROCHE AG
Switzerland
Address
Grenzacherstrasse 124
4070 Basel

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rob England (-)
UCB Biopharma SPRL
Belgium
Address
Allée De La Recherche
1070 Brussels

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Dresse (Mr)
Janssen Biologics BV
Netherlands
Address
Einsteinweg
2333 CD Leiden

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Administrative Contact
Hendrik Carel Meijerink (Mr)
AMGEN
Belgium
Address
Telecomlaan 5-7
1831 Diegem

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Simon Gibbs (Mr.)
MERCK SHARP & DOHME CORP
United States
Address
One Merck Drive
08889 Whitehouse Station Nj

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Karen McGurk (Director)