Biomarkers For Enhanced Vaccine Safety

Project Information

BIOVACSAFE

Grant agreement ID: 115308

Project closed

Start date 1 March 2012

End date 31 August 2018

Funded under

• Specific Programme "Cooperation": Joint Technology Initiatives

Total cost € 30 931 370,00

EU contribution € 17 408 770,00

Coordinated by

GLAXOSMITHKLINE VACCINES SRL
Italy

Objective

BioVacSafe is a concise consortium of selected academic, public, and SME participants used to co-working in industry-led projects, organised into focused Activity Cores to generate knowledge and tools to benchmark licensed vaccine reactogenicity, and create practical and generalizable guidelines and techniques to enhance immunosafety of novel vaccines from pre-development to post-marketing surveillance. A compact interlocking structure provides efficient and cost-effective goal delivery, while offering the full spectrum of functionality and capacity to match the needs for predictive biomarkers and models of inflammation/autoimmunity and clinical events classification. A Technology Core has transcriptomics, genotyping, proteomics, metabolomics and data mining, with depth and capacity to discover, validate and distribute novel biomarkers. A Models Core has a full range of ex vivo/in vivo murine, small animal and non-human primate models of inflammation and biomarker discovery, with advanced immunology and imaging. A Clinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety from small intensive trials to large-scale studies of adult, paediatric and other populations. A Populations Core has population-scale biobank discovery, clinical cohorts (with globalisation capability, autoimmune, chronic, inflammatory and infectious disease groups), large-scale genotyping and sequencing, and a safely accessible central database for online analyses of large datasets. A Regulatory Core with expertise to synthesise outputs to generate and disseminate classifications, guidelines, reference standards for vaccine development, and inform EFPIA activities. A Management Core with track record of successful public-private projects ensures Cores interoperate to maximise discovery - validation - application - re-discovery cycles, to deliver project goals on time, within budget, while maximising interactions with other actors (EFPIA, FDA, EMA).

Fields of science

• natural sciences › biological sciences › zoology › mammalogy › primatology
• medical and health sciences › health sciences › infectious diseases
• natural sciences › computer and information sciences › data science › data mining
• medical and health sciences › basic medicine › immunology
• medical and health sciences › basic medicine › pharmacology and pharmacy › pharmaceutical drugs › vaccines

Programme(s)

• FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives

Topic(s)

• IMI-JU-03-2010-03 - Immunosafety Of Vaccines – New Biomarkers Associated With Adverse Events (Early Inflammation, Autoimmune Diseases And Allergy)

Call for proposal

IMI-JU-03-2010
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

GLAXOSMITHKLINE VACCINES SRL

• EU contribution: No data
• Address: VIA FIORENTINA 1 ; 53100 SIENA ; Italy
• Region: Centro (IT) › Toscana › Siena
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Francesco Gulli (Dr)
• Principal investigator: Giuseppe Del Giudice (Dr)
• Total cost: No data

Participants (21)

UNIVERSITY OF SURREY

United Kingdom

• EU contribution: € 3 711 632,00
• Address: Stag Hill ; GU2 7XH Guildford
• Region: South East (England) › Surrey, East and West Sussex › West Surrey
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Maria Sega-Buhalis (Ms)
• Total cost: No data

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

• EU contribution: € 2 531 522,00
• Address: HOFGARTENSTRASSE 8 ; 80539 Munchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Research Organisations
• Administrative Contact: Olaf Kostbahn (Mr)
• Total cost: No data

LIVERPOOL SCHOOL OF TROPICAL MEDICINE

Participation ended

United Kingdom

• EU contribution: € 216 203,00
• Address: PEMBROKE PLACE ; L35QA LIVERPOOL 3
• Region: North West (England) › Merseyside › Liverpool
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Sian Roberts (Mrs)
• Total cost: No data

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

• EU contribution: € 399 999,00
• Address: RUE LEBLANC 25 ; 75015 PARIS 15
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Olivier LEROY (Mr)
• Total cost: No data

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

• EU contribution: € 2 336 660,00
• Address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON
• Region: London › Inner London — West › Westminster
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Tatjana Palalic (Ms)
• Total cost: No data

UNIVERSITA DEGLI STUDI DI SIENA

Italy

• EU contribution: € 1 029 564,00
• Address: VIA BANCHI DI SOTTO 55 ; 53100 Siena
• Region: Centro (IT) › Toscana › Siena
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Angelo Riccaboni (Prof)
• Total cost: No data

ImmunArray Ltd

Israel

• EU contribution: € 925 820,00
• Address: Bergman ; 76705 Rehovot
• Administrative Contact: ELI SAHAR (Dr)
• Total cost: No data

CHALMERS TEKNISKA HOGSKOLA AB

Sweden

• EU contribution: € 762 212,00
• Address: - ; 412 96 GOTEBORG
• Region: Södra Sverige › Västsverige › Västra Götalands län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Karin Westerlund (Ms)
• Total cost: No data

HEALTH PROTECTION AGENCY HPA

Participation ended

United Kingdom

• EU contribution: € 566,00
• Address: BUCKINGHAM PALACE ROAD 151 ; SW1W 9SZ London
• Activity type: Research Organisations
• Administrative Contact: Amanda King (Mrs)
• Total cost: No data

UNIVERSITEIT UTRECHT

Netherlands

• EU contribution: € 839 510,00
• Address: HEIDELBERGLAAN 8 ; 3584 CS Utrecht
• Region: West-Nederland › Utrecht › Utrecht
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ricardo Fernandez Reyes (Mr)
• Total cost: No data

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Participation ended

Germany

• EU contribution: € 356 306,00
• Address: Chariteplatz 1 ; 10117 Berlin
• Region: Berlin › Berlin › Berlin
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Eveline Fräßdorf (Ms)
• Total cost: No data

UNIVERSITEIT GENT

Belgium

• EU contribution: € 2 000 007,00
• Address: SINT PIETERSNIEUWSTRAAT 25 ; 9000 Gent
• Region: Vlaams Gewest › Prov. Oost-Vlaanderen › Arr. Gent
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Margo Baele (Dr)
• Total cost: No data

GOETEBORGS UNIVERSITET

Sweden

• EU contribution: € 777 000,00
• Address: VASAPARKEN ; 405 30 Goeteborg
• Region: Södra Sverige › Västsverige › Västra Götalands län
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Ellen Rydberg (Dr)
• Total cost: No data

ISLENSK ERFDAGREINING EHF

Participation ended

Iceland

• EU contribution: € 29 786,00
• Address: STURLUGOTU 8 ; 101 Reykjavik
• Region: Ísland › Ísland › Höfuðborgarsvæði
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Frosti JONSSON (Mr.)
• Total cost: No data

STATENS SERUM INSTITUT

Denmark

• EU contribution: € 679 216,00
• Address: ARTILLERIVEJ 5 ; 2300 Kobenhavn S
• Region: Danmark › Hovedstaden › Byen København
• Activity type: Research Organisations
• Administrative Contact: Else Marie Agger (Dr)
• Total cost: No data

GLAXOSMITHKLINE BIOLOGICALS SA

Belgium

• EU contribution: No data
• Address: RUE DE L INSTITUT 89 ; 1330 Rixensart
• Region: Région wallonne › Prov. Brabant Wallon › Arr. Nivelles
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Sally Miles (-)
• Total cost: No data

SANOFI PASTEUR SA

France

• EU contribution: No data
• Address: 14 ESPACE HENRY VALLEE ; 69007 Lyon
• Region: Auvergne-Rhône-Alpes › Rhône-Alpes › Rhône
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Sarah Gould (Mrs)
• Total cost: No data

CDISC EUROPE FOUNDATION FONDATION

Belgium

• EU contribution: No data
• Address: PLACE MARCEL BROODTHAERS 8 SOUTH CENTER TITANIUM 4TH FLOOR ; 1060 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Research Organisations
• Administrative Contact: Shirley Williams (Ms)
• Total cost: No data

VISMEDERI SRL

Italy

• EU contribution: No data
• Address: STRADA DEL PETRICCIO E BELRIGUARDO 35 ; 53100 Siena Si
• Region: Centro (IT) › Toscana › Siena
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Chiara Gentile (Dr.)
• Total cost: No data

Department of Health

United Kingdom

• EU contribution: € 497 736,00
• Address: Quarry House, Quarry Hill ; LS2 7UE Leeds
• Region: Yorkshire and the Humber › West Yorkshire › Leeds
• Activity type: Research Organisations
• Administrative Contact: amanda king (Mrs)
• Total cost: No data

ST GEORGE'S HOSPITAL MEDICAL SCHOOL

United Kingdom

• EU contribution: € 315 031,00
• Address: CRANMER TERRACE ; SW17 0RE London
• Region: London › Inner London — West › Wandsworth
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Jane Boland (Miss)
• Total cost: No data