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Biomarkers For Enhanced Vaccine Safety

Objective

BioVacSafe is a concise consortium of selected academic, public, and SME participants used to co-working in industry-led projects, organised into focused Activity Cores to generate knowledge and tools to benchmark licensed vaccine reactogenicity, and create practical and generalizable guidelines and techniques to enhance immunosafety of novel vaccines from pre-development to post-marketing surveillance. A compact interlocking structure provides efficient and cost-effective goal delivery, while offering the full spectrum of functionality and capacity to match the needs for predictive biomarkers and models of inflammation/autoimmunity and clinical events classification. A Technology Core has transcriptomics, genotyping, proteomics, metabolomics and data mining, with depth and capacity to discover, validate and distribute novel biomarkers. A Models Core has a full range of ex vivo/in vivo murine, small animal and non-human primate models of inflammation and biomarker discovery, with advanced immunology and imaging. A Clinical Core has capability to safely and efficiently distribute clinical studies of vaccine immunosafety from small intensive trials to large-scale studies of adult, paediatric and other populations. A Populations Core has population-scale biobank discovery, clinical cohorts (with globalisation capability, autoimmune, chronic, inflammatory and infectious disease groups), large-scale genotyping and sequencing, and a safely accessible central database for online analyses of large datasets. A Regulatory Core with expertise to synthesise outputs to generate and disseminate classifications, guidelines, reference standards for vaccine development, and inform EFPIA activities. A Management Core with track record of successful public-private projects ensures Cores interoperate to maximise discovery - validation - application - re-discovery cycles, to deliver project goals on time, within budget, while maximising interactions with other actors (EFPIA, FDA, EMA).

Field of science

  • /social sciences/sociology/globalization
  • /medical and health sciences/basic medicine/immunology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /natural sciences/computer and information sciences/data science/data mining
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines

Call for proposal

IMI-JU-03-2010
See other projects for this call

Funding Scheme

JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI)

Coordinator

GLAXOSMITHKLINE VACCINES SRL
Address
Via Fiorentina 1
53100 Siena
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact

Participants (21)

UNIVERSITY OF SURREY
United Kingdom
EU contribution
€ 3 808 116
Address
Stag Hill
GU2 7XH Guildford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 2 451 932
Address
Hofgartenstrasse 8
80539 Munich
Activity type
Other
Administrative Contact
LIVERPOOL SCHOOL OF TROPICAL MEDICINE

Participation ended

United Kingdom
EU contribution
€ 216 203
Address
Pembroke Place
L35QA Liverpool
Activity type
Higher or Secondary Education Establishments
Administrative Contact
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 399 999
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 2 336 660
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 1 029 564
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
ImmunArray Ltd
Israel
EU contribution
€ 925 820
Address
Bergman
76705 Rehovot
Administrative Contact
CHALMERS TEKNISKA HOEGSKOLA AB
Sweden
EU contribution
€ 762 212
Address
-
41296 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Public Health England an Executive Agency of the Dept of Health

Participation ended

United Kingdom
EU contribution
€ 566
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 839 510
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Participation ended

Germany
EU contribution
€ 356 306
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
UNIVERSITEIT GENT
Belgium
EU contribution
€ 2 000 007
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 777 000
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
ISLENSK ERFDAGREINING EHF

Participation ended

Iceland
EU contribution
€ 29 786
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
STATENS SERUM INSTITUT
Denmark
EU contribution
€ 679 216
Address
Artillerivej 5
2300 Kobenhavn S
Activity type
Research Organisations
Administrative Contact
GLAXOSMITHKLINE BIOLOGICALS SA
Belgium
Address
Rue De L Institut 89
1330 Rixensart
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
SANOFI PASTEUR SA
France
Address
Avenue Pont Pasteur, 2
69007 Lyon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
CDISC EUROPE FOUNDATION FONDATION
Belgium
Address
Place Marcel Broodthaers 8 South Center Titanium 4Th Floor
1060 Bruxelles
Activity type
Research Organisations
Administrative Contact
VISMEDERI SRL
Italy
Address
Strada Del Petriccio E Belriguardo 35
53100 Siena Si
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Department of Health
United Kingdom
EU contribution
€ 497 736
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
Administrative Contact
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 315 031
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact