Objective
Resolution of acute inflammation, involving limiting further leukocyte recruitment, apoptosis and clearance
of inflammatory cells via macrophages as well as egress of the inflammatory cells, is operative in acute
inflammation but dysfunctional in chronic inflammatory disease. In the latter scenario, the retention and
activation of leukocytes in the inflamed tissue linked with failure to resolve inflammation contributes to
perpetuation of organ damage and loss of homeostasis. Interestingly, persistent inflammation in insulintarget
organs, such as the adipose tissue and the liver in the context of obesity significantly contributes to
development of insulin resistance (IR), diabetes and non-alcoholic fatty liver disease (NAFLD). So far,
investigations have mainly addressed obesity-related inflammatory mechanisms in the AT and rather less in
other metabolic organs, e.g. the liver. Therefore, the aims of this proposal are: (i) To characterize in the
context of obesity-related metabolic disease novel processes mediating inflammatory cell retention,
especially in the liver. In this context, we will also address the novel hypothesis that adhesive interactions of
inflammatory cells (with e.g. parenchymal cells) in the metabolically challenged environment of obese
organs may activate them via alterations in their cellular metabolism, thereby contributing to perpetuation of
inflammation. (ii) To understand resolution of inflammation including inflammatory cell egress from
metabolic organs, especially from the liver in metabolic-inflammatory disease. To this end, we will also
utilize models of acute inflammation, which is capable to resolve, in order to understand resolution principles
and apply them to non-resolving metabolic-inflammatory disease. In this regard, we will also assess the
therapeutic potential of novel inflammation-modulating factors identified by our lab.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine hepatology
- medical and health sciences basic medicine physiology homeostasis
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-COG - Consolidator Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2015-CoG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
01069 Dresden
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.