Objective Resolution of acute inflammation, involving limiting further leukocyte recruitment, apoptosis and clearanceof inflammatory cells via macrophages as well as egress of the inflammatory cells, is operative in acuteinflammation but dysfunctional in chronic inflammatory disease. In the latter scenario, the retention andactivation of leukocytes in the inflamed tissue linked with failure to resolve inflammation contributes toperpetuation of organ damage and loss of homeostasis. Interestingly, persistent inflammation in insulintargetorgans, such as the adipose tissue and the liver in the context of obesity significantly contributes todevelopment of insulin resistance (IR), diabetes and non-alcoholic fatty liver disease (NAFLD). So far,investigations have mainly addressed obesity-related inflammatory mechanisms in the AT and rather less inother metabolic organs, e.g. the liver. Therefore, the aims of this proposal are: (i) To characterize in thecontext of obesity-related metabolic disease novel processes mediating inflammatory cell retention,especially in the liver. In this context, we will also address the novel hypothesis that adhesive interactions ofinflammatory cells (with e.g. parenchymal cells) in the metabolically challenged environment of obeseorgans may activate them via alterations in their cellular metabolism, thereby contributing to perpetuation ofinflammation. (ii) To understand resolution of inflammation including inflammatory cell egress frommetabolic organs, especially from the liver in metabolic-inflammatory disease. To this end, we will alsoutilize models of acute inflammation, which is capable to resolve, in order to understand resolution principlesand apply them to non-resolving metabolic-inflammatory disease. In this regard, we will also assess thetherapeutic potential of novel inflammation-modulating factors identified by our lab. Fields of science medical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicinehepatologymedical and health sciencesbasic medicinephysiologyhomeostasismedical and health scienceshealth sciencesnutritionobesity Keywords Inflammation Leukocyte adhesion obesity Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-CoG-2015 - ERC Consolidator Grant Call for proposal ERC-2015-CoG See other projects for this call Funding Scheme ERC-COG - Consolidator Grant Host institution TECHNISCHE UNIVERSITAET DRESDEN Net EU contribution € 1 953 250,00 Address HELMHOLTZSTRASSE 10 01069 Dresden Germany See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 953 250,00 Beneficiaries (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all TECHNISCHE UNIVERSITAET DRESDEN Germany Net EU contribution € 1 953 250,00 Address HELMHOLTZSTRASSE 10 01069 Dresden See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 953 250,00