Objetivo At least 10% of mothers and 5% of fathers have a mental illness. Family, educational and social lives of children and adolescents with parental mental illness (CAPRI) are disrupted by deprivation and repeated hospitalisation. This is an urgent political and public health concern. The Child and Adolescent Mental Health in Europe (CAMHEE) report urges us ‘to acknowledge and attend to the needs of children and families with parental mental health.. ’ recommending better information on CAPRI risks and resilience so interventions can target those at highest risk. This groundbreaking interdisciplinary programme exploits my unique combination of expertise in epidemiology and neuroscience to deliver on CAMHEE objectives for CAPRI. Previous work focuses on these ‘high risk’ children primarily to examine mental illness heritability. In a crucial departure from this, Work Packages (WP) 1 and 2 exploit my collaborations in Sweden and Australia to create unique linkage across 3 population datasets. This will detail CAPRI numbers and a broad range of life outcomes disentangling effects of social adversity over time. But population epidemiology alone cannot reveal how risk creates effects in individuals. To understand ‘how’ to identify ‘who’ we target for costly interventions, WP 3 links the epidemiology with powerful neuroimaging (near infrared spectroscopy NIRS) to discover which at-risk infants of mothers with severe mental illness show abnormal cognitive development at the level of individual brain. This work capitalises on my role at the University of Manchester, one of the leading academic psychiatry and imaging centres in the UK, to create a new Centre in Bioepidemiology. My future aim is that epidemiological profiling combined with NIRS biomarkers of cognition in individuals will identify which high risk children need what intervention. Future work can then evaluate different interventions and fits seamlessly with my research goal to improve the life outcomes of CAPRI. Ámbito científico medical and health sciencesclinical medicinepsychiatrymedical and health scienceshealth sciencespublic healthepidemiologysocial sciencessociologydemographyfertilitymedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesclinical medicineoncology Palabras clave Children parents family mental health high risk resilience vulnerability national population database epidemiology near infrared spectroscopy Programa(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Tema(s) ERC-CoG-2015 - ERC Consolidator Grant Convocatoria de propuestas ERC-2015-CoG Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-COG - Consolidator Grant Institución de acogida THE UNIVERSITY OF MANCHESTER Aportación neta de la UEn € 1 615 962,50 Dirección OXFORD ROAD M13 9PL Manchester Reino Unido Ver en el mapa Región North West (England) Greater Manchester Manchester Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 615 962,50 Beneficiarios (2) Ordenar alfabéticamente Ordenar por aportación neta de la UE Ampliar todo Contraer todo THE UNIVERSITY OF MANCHESTER Reino Unido Aportación neta de la UEn € 1 615 962,50 Dirección OXFORD ROAD M13 9PL Manchester Ver en el mapa Región North West (England) Greater Manchester Manchester Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 1 615 962,50 KAROLINSKA INSTITUTET Suecia Aportación neta de la UEn € 383 375,00 Dirección Nobels Vag 5 17177 Stockholm Ver en el mapa Región Östra Sverige Stockholm Stockholms län Tipo de actividad Higher or Secondary Education Establishments Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Participación en los programas de I+D de la UE Opens in new window Red de colaboración de HORIZON Opens in new window Coste total € 383 375,00