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Regulation of mitochondrial expression

Obiettivo

Mitochondria are essential organelles found in every eukaryotic cell, required to convert food into usable energy. The
mitochondrial oxidative phosphorylation (OXPHOS) system, which produces the majority of cellular energy in the form of
ATP, is controlled by two distinct genomes: the nuclear and the mitochondrial genome (mtDNA). Mutations in mitochondrial
genes encoded by either genome could cause diseases affecting OXPHOS system, called mitochondrial diseases, whose
prevalence has been estimated to be ≈1:8500. Moreover, dysfunction of mitochondrial OXPHOS system has emerged as a
key factor in a myriad of “common” diseases, including neurodegenerative and metabolic disorders like Parkinson’s and
Alzheimer’s Disease, Type 2 Diabetes, and was linked to aging process. Despite all this, it is surprising that our
understanding of the mechanisms governing the mitochondrial gene expression and its associated pathologies remain
superficial and therapeutic interventions unexplored. The basic machineries for mtDNA replication, mtDNA transcription and
mitochondrial translation are known, but the regulation of these processes in response to metabolic demands is poorly
understood. The complex nature of mitochondrial gene expression that relies on two different genomes calls for a
multidisciplinary approach where different teams of researchers join forces. Studies in this area are not only of basic
scientific interest but may also provide new avenues towards treatment of mitochondrial dysfunction in a variety of human
diseases.
The key aim of the REMIX Network is combine the skills of European research groups to provide strategic training of the
next generation of scientists through a programme that will progress in the elucidation of the molecular mechanisms and
pathways that regulate mitochondrial gene expression.

Campo scientifico

Programma(i)

Argomento(i)

Invito a presentare proposte

H2020-MSCA-ITN-2016

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Meccanismo di finanziamento

MSCA-ITN-ETN - European Training Networks

Coordinatore

UNIVERSITAT ZU KOLN
Contribution nette de l'UE
€ 643 809,24
Indirizzo
ALBERTUS MAGNUS PLATZ
50931 Koln
Germania

Mostra sulla mappa
Regione
Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 643 809,24

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Ultimo aggiornamento: 23 Agosto 2022

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Permalink: https://cordis.europa.eu/project/id/721757/it

European Union, 2024