Project description DEENESFRITPL Holistic insight into osteoarthritis Osteoarthritis (OA) is a common degenerative joint disease that primarily affects the elderly but can also impact younger individuals and athletes. OA causes joint pain, limits mobility, and reduces independence and overall quality of life. While various risk factors have been implicated in OA development, there is a need to integrate patient-specific information at the cellular, tissue, organ, and body levels. The EU-funded OACTIVE project aims to address this gap by adopting a holistic approach that combines patient-specific data with information from biomarkers, behaviour modelling, and environmental factors. Researchers aim to develop personalised interventions for delaying the onset and slowing down the progression of OA also with the use of augmented reality for increased patient motivation and engagement. Show the project objective Hide the project objective Objective Osteoarthritis (OA) is a degenerative disease of the articular cartilage and the most common form of arthritis that causes joint pain, mobility limitation and, thus, reduces independence and overall quality of life. Although the usual population associated with the condition is the elderly (65 years old ranges from 12- 30%), who are mostly inactive, athletes and younger individuals are also susceptible. Whilst the available data have implicated the role of the various modifiable or non-modifiable risk factors in the development and progression of OA, no study has conclusively explored the interaction and integration of other information sets in a patient-specific manner. The current OACTIVE project intents to make a significant leap forward adopting a multi-scale holistic approach where patient-specific information from various levels, including cell, tissue, organ and whole body will be integrated and combined with information from other sources such as biochemical/inflammatory biomarkers, behaviour modeling and social/environmental risk factors to generate robust predictors for new personalised interventions for delaying onset and slowing down progression of OA. OACTIVE targets to patient-specific OA prediction and interventions by using a combination of mechanistic, phenomenological computational models, simulations and big data analytics. Once constructed, these models will be used to simulate and predict optimal treatments, better diagnostics, and improved patient outcomes. Overcoming the limitation of the current treatment interventions, Augmented Reality empowered interventions will be developed in a personalised framework allowing patients experience the treatment as more enjoyable, resulting in greater motivation, engagement, and training adherence. OACTIVE’s mission is to improve healthcare by transforming and accelerating the OA diagnosis and prediction based on a more comprehensive understanding of disease pathophysiology, dynamics, and patient outcomes. Fields of science medical and health sciencesclinical medicinerheumatologymedical and health sciencesbasic medicinephysiologypathophysiologynatural sciencescomputer and information sciencesdata sciencebig datanatural sciencescomputer and information sciencesartificial intelligencemachine learningdeep learningnatural sciencescomputer and information sciencessoftwaresoftware applicationssimulation software Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.5. - Methods and data Topic(s) SC1-PM-17-2017 - Personalised computer models and in-silico systems for well-being Call for proposal H2020-SC1-2016-2017 See other projects for this call Sub call H2020-SC1-2017-CNECT-2 Funding Scheme RIA - Research and Innovation action Coordinator EDEX - EDUCATIONAL EXCELLENCE CORPORATION LIMITED Net EU contribution € 521 000,00 Address Makedonitisas avenue 46 1700 Nicosia Cyprus See on map Region Κύπρος Κύπρος Κύπρος Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 521 000,00 Participants (12) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS Greece Net EU contribution € 506 875,00 Address Charilaou thermi road 6 km 57001 Thermi thessaloniki See on map Region Βόρεια Ελλάδα Κεντρική Μακεδονία Θεσσαλονίκη Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 506 875,00 LIVERPOOL JOHN MOORES UNIVERSITY United Kingdom Net EU contribution € 444 721,25 Address Rodney street 2 egerton court L3 5UX Liverpool See on map Region North West (England) Merseyside Liverpool Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 444 721,25 PANEPISTIMIO PATRON Greece Net EU contribution € 431 250,00 Address University campus rio patras 265 04 Rio patras See on map Region Κεντρική Ελλάδα Δυτική Ελλάδα Αχαΐα Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 431 250,00 SMARTEX SRL Italy Net EU contribution € 456 062,50 Address Via della croce rossa 82 59100 Prato See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Centro (IT) Toscana Prato Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 456 062,50 KATHOLIEKE UNIVERSITEIT LEUVEN Belgium Net EU contribution € 354 062,50 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 354 062,50 CENTER FOR TECHNOLOGY RESEARCH ANDINNOVATION (CETRI) LTD Cyprus Net EU contribution € 477 000,00 Address 77, john kennedy avenue 1077 Nicosia See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Κύπρος Κύπρος Κύπρος Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 477 000,00 ACONDICIONAMIENTO TARRASENSE ASSOCIACION Spain Net EU contribution € 422 500,00 Address Carrer de la innovacio 2 08225 Terrassa See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 422 500,00 FONDAZIONE RI.MED Italy Net EU contribution € 399 062,50 Address Via bandiera 11 90133 Palermo See on map Region Isole Sicilia Palermo Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 399 062,50 TIMELEX Belgium Net EU contribution € 186 750,00 Address Joseph stevensstraat 7 1000 Bruxelles / brussel See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 186 750,00 AXIA INNOVATION UG Germany Net EU contribution € 248 750,00 Address Fritz-hommel-weg 4 80805 Munchen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 248 750,00 ANIMUS KENTRO APOTHERAPEIAS KAI APOKATASTASIS ANONYMI ETAIRIA Greece Net EU contribution € 218 750,00 Address 8 km larissa - trikala 41500 Larissa See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Κεντρική Ελλάδα Θεσσαλία Λάρισα Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 218 750,00 FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA Spain Net EU contribution € 317 250,00 Address Av fernando abril martorell 106 46026 Valencia See on map Region Este Comunitat Valenciana Valencia/València Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 317 250,00