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Advanced personalised, multi-scale computer models preventing OsteoArthritis

Objective

Osteoarthritis (OA) is a degenerative disease of the articular cartilage and the most common form of arthritis that causes joint pain, mobility limitation and, thus, reduces independence and overall quality of life. Although the usual population associated with the condition is the elderly (65 years old ranges from 12- 30%), who are mostly inactive, athletes and younger individuals are also susceptible. Whilst the available data have implicated the role of the various modifiable or non-modifiable risk factors in the development and progression of OA, no study has conclusively explored the interaction and integration of other information sets in a patient-specific manner. The current OACTIVE project intents to make a significant leap forward adopting a multi-scale holistic approach where patient-specific information from various levels, including cell, tissue, organ and whole body will be integrated and combined with information from other sources such as biochemical/inflammatory biomarkers, behaviour modeling and social/environmental risk factors to generate robust predictors for new personalised interventions for delaying onset and slowing down progression of OA. OACTIVE targets to patient-specific OA prediction and interventions by using a combination of mechanistic, phenomenological computational models, simulations and big data analytics. Once constructed, these models will be used to simulate and predict optimal treatments, better diagnostics, and improved patient outcomes. Overcoming the limitation of the current treatment interventions, Augmented Reality empowered interventions will be developed in a personalised framework allowing patients experience the treatment as more enjoyable, resulting in greater motivation, engagement, and training adherence. OACTIVE’s mission is to improve healthcare by transforming and accelerating the OA diagnosis and prediction based on a more comprehensive understanding of disease pathophysiology, dynamics, and patient outcomes.

Call for proposal

H2020-SC1-2016-2017

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Sub call

H2020-SC1-2017-CNECT-2

Coordinator

EDEX - EDUCATIONAL EXCELLENCE CORPORATION LIMITED
Net EU contribution
€ 521 000,00
Address
Makedonitisas Avenue 46
1700 Nicosia
Cyprus

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Region
Κύπρος Κύπρος Κύπρος
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (12)

ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS
Greece
Net EU contribution
€ 506 875,00
Address
Charilaou Thermi Road 6 Km
57001 Thermi Thessaloniki

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Region
Θεσσαλονίκη Κεντρική Μακεδονία Βόρεια Ελλάδα
Activity type
Research Organisations
Non-EU contribution
€ 0,00
LIVERPOOL JOHN MOORES UNIVERSITY
United Kingdom
Net EU contribution
€ 444 721,25
Address
Rodney Street 2 Egerton Court
L3 5UX Liverpool

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Region
North West (England) Merseyside Liverpool
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
PANEPISTIMIO PATRON
Greece
Net EU contribution
€ 431 250,00
Address
University Campus Rio Patras
265 04 Rio Patras

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Region
Αχαΐα Δυτική Ελλάδα Κεντρική Ελλάδα
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SMARTEX SRL
Italy
Net EU contribution
€ 456 062,50
Address
Via Della Croce Rossa 82
59100 Prato

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Toscana Prato
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
Net EU contribution
€ 354 062,50
Address
Oude Markt 13
3000 Leuven

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTER FOR TECHNOLOGY RESEARCH ANDINNOVATION (CETRI) LTD
Cyprus
Net EU contribution
€ 477 000,00
Address
77, John Kennedy Avenue
1077 Nicosia

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Κύπρος Κύπρος Κύπρος
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ACONDICIONAMIENTO TARRASENSE ASSOCIACION
Spain
Net EU contribution
€ 422 500,00
Address
Carrer De La Innovacio 2
08225 Terrassa

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FONDAZIONE RI.MED
Italy
Net EU contribution
€ 399 062,50
Address
Via Bandiera 11
90133 Palermo

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Region
Isole Sicilia Palermo
Activity type
Research Organisations
Non-EU contribution
€ 0,00
TIME.LEX
Belgium
Net EU contribution
€ 186 750,00
Address
Joseph Stevensstraat 7
1000 Brussel

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
AXIA INNOVATION UG
Germany
Net EU contribution
€ 248 750,00
Address
Turkenstrasse 29
80799 Munchen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ANIMUS KENTRO APOTHERAPEIAS KAI APOKATASTASIS ANONYMI ETAIRIA
Greece
Net EU contribution
€ 218 750,00
Address
8 Km Larissa - Trikala
41500 Larissa

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Λάρισα Θεσσαλία Κεντρική Ελλάδα
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
Spain
Net EU contribution
€ 317 250,00
Address
Av Fernando Abril Martorell 106
46026 Valencia

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Region
Este Comunitat Valenciana Valencia/València
Activity type
Research Organisations
Non-EU contribution
€ 0,00