Objetivo The general objective of the proposed concerted action is to make improvements in radiotherapy accessible for each patient in each country in Europe. This goal will be pursued by initiating clinical trials and instruction of national reference centres with the following aims. 1. To investigate the therapeutic gain that can be achieved by adapting the individual irradiation fractionation scheme to the tumour growth rate. 2. To investigate the possibility of improving local control, survival and reducing serious side effects by comparing different dose levels of radiation. 3. Designing protocols for controlling treatment accuracy with the help of portal imaging and searching for causes of inaccuracies in the treatment chain. Project outline: 1. Trial A: fractionation studies in head and neck cancer. A randomized phase lll trial will be executed in which all patients will be injected with lUdR and biopsied prior to radiotherapy in order to assess the potential tumour doubling time. The patients will then be stratified and randomized according to the tumour growth rate. Within this trial the known advantages of different fractionation schedules will be further exploited. 2. Trial B: dose-effect study in breast cancer. A randomized phase lll clinical trial will be executed comparing: a) conventional irradiation treatment b) 10% higher radiation dose to the primary tumour area 3. Control of treatment accuracy. Standard protocols for measurement and control of the treatment accuracy through the use of portal films and electronic portal imaging devices will be developed. Software and instruction for the analysis of portal films and images obtained with an electronic portal imaging device developed in the central coordinating centre will be made available to the participating centres to analyse treatment deviations. Programa(s) IC-PECO/COPERNICUS - Scientific and technological cooperation between the European Community and European non-member countries, 1992- Tema(s) 0201 - CEEC participation in BIOMEDICAL AND HEALTH RESEARCH programme Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador THE NETHERLANDS CANCER INSTITUTE/ANTONI VAN LEEUWENHOEK HOSPITAL Aportación de la UE Sin datos Dirección 121,Plesmanlaan 121 1066 CX AMSTERDAM Países Bajos Ver en el mapa Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Academic Medical School in Gdansk Polonia Aportación de la UE Sin datos Dirección 7,Ul.Debinki 80 211 Gdansk Ver en el mapa Coste total Sin datos Institute of Oncology Ljubljana Eslovenia Aportación de la UE Sin datos Dirección 2,Zaloska 61105 Ljubljana Ver en el mapa Coste total Sin datos