Objetivo The objectives of the proposal are to assess in women experiencing malaria in pregnancy if there is an influence of material anaemia on birthweight that is independent of malaria and to determine the difference in malaria prevalence, infant morbidity and growth between infants born with and without fetal anaemia. The proposal allows the opportunity for collaboration between doctors at the New Medical School in Malawi, and malaria field scientists in Liverpool, England and Leiden, The Netherlands. The project is linked with the Liverpool-Malawi Severe Malaria Project. Two study designs will be employed. A preliminary case-control study will be undertaken to quantify the contribution of anaemia and iron status to low birthweight and to investigate the association between maternal anaemia and iron status with fetal anaemia. 400 cases and controls will be studied. Subsequently a cohort study design is employed with follow-up of 200 newborn babies for twelve months. This study will test the hypothesis that birth haemoglobin relates to malaria and morbidity risk in infants. Further studies will be done on malaria drug resistance in vivo in infants and on the nature of severe anaemia in infants admitted to hospital. These studies will address unanswered questions concerning the prevalence of anaemia in infants in a highly malarious area; the relationship between fetal anaemia and clinical risk in infancy, and the relationship between maternal anaemia and iron status and lowbirthweight risk. The project provides the opportunity for training to Ph. D level of a Malawian doctor and a European Dutch counterpart. The project is considered high priority because of the magnitude of drug resistant malaria and the high prevalence of anaemia requiring blood transfusion in malarious areas of developing countries. It should enable appropriate intervention strategies to be identified for women in pregnancy and infants. Ámbito científico medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemedical and health sciencesclinical medicineobstetrics Programa(s) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador LIVERPOOL SCHOOL OF TROPICAL MEDICINE Aportación de la UE Sin datos Dirección Pembroke Place LIVERPOOL Reino Unido Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos Participantes (2) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Business Unit of TNO Built Environment and Geosciences Países Bajos Aportación de la UE Sin datos Dirección Van Mourik Broekmanweg 6 2628 XE DELFT Ver en el mapa Enlaces Sitio web Opens in new window Coste total Sin datos University of Malawi Malaui Aportación de la UE Sin datos Dirección Blantyre Ver en el mapa Coste total Sin datos
