Objetivo - The general and long term goal is to develop the new field of locust peptide neurotransmitters and hormones to such a stage that organic chemists and molecular biologists can engage in the development of practical applications for locust control.- In the course of this project, the following signalling peptides have been identified in Schistocerca : 8 allatostatins and the coding gene, salivation peptide, a few myotropins, the releasing factor for adipokinetic hormone, neuroparsin and ovary maturating parsin. Trypsin modulating oostatic factor was isolated from mature ovaries. It is a small peptide but two amino acid residues could as yet not be identified. A second purification is being attempted. Four chymotrypsin inhibitors and the coding genes were also fully characterised. In addition, a trypsin inhibitor was found but determining its sequence continues to be difficult. A novel inhibitor of juvenile hormone biosynthesis was found in the fungus Penicilium. A variety of physiological results were obtained. An important discovery in the study of gregarization is the finding that isolation of the eggs soon after they are laid results in a hundred percent solitary animals.Follow up- During the last year of the project, efforts are made to develop practical applications. Leuven and Marrakech concentrate on effects on feeding behaviour and food digestion; Bordeaux, Valencia and Rabat on reproduction and juvenile hormone biosynthesis; and Tunis continues its studies on gregarization.- The project focuses on the identification of the peptides that control the biosynthesis of juvenile hormone, ecdysone, trypsin/chymotrypsin and on ones that regulate reproduction and food intake/digestion. The isolation and sequence determination are carried out in Leuven and Bordeaux, with the help of the partners in Morocco (Rabat, Marrakech) and in Tunis. Leuven concentrates on allatostatins, myotropins, ecdysiostatins and on peptides interfering with digestion in the gut, the latter in close collaboration with Marrakech. Bordeaux and Rabat concentrate on neuroparsins and on ovary maturating parsin. Bordeaux and Valencia do most of the research concerning the biosynthesis of juvenile hormone. Tunis is especially involved in the study of the mechanisms of gregarization. All laboratories are involved in the study of the physiological role of the different peptides. In their respective domains, they also search for practical applications . Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesnatural sciencesbiological sciencesmicrobiologymycologymedical and health sciencesbasic medicinephysiologymedical and health sciencesclinical medicineendocrinologynatural scienceschemical sciencesorganic chemistryamines Programa(s) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Tema(s) Data not available Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador Katholieke Universiteit Leuven Aportación de la UE Sin datos Dirección 59,Naamsestraat 3000 Leuven Bélgica Ver en el mapa Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Institut National d'Agronomie de Tunisie Túnez Aportación de la UE Sin datos Dirección 43,Avenue Charles Nicolle Tunis Mahrajene Ver en el mapa Coste total Sin datos Universidad de Valencia España Aportación de la UE Sin datos Dirección 6,Calle Lauria 46002 Valencia Ver en el mapa Coste total Sin datos Université Mohammed V Marruecos Aportación de la UE Sin datos Dirección Avenue Ibn Battouta Rabat Ver en el mapa Coste total Sin datos Université de Bordeaux I Francia Aportación de la UE Sin datos Dirección Avenue des Facultés 33405 Talence Ver en el mapa Coste total Sin datos
