Objective The project has the objective of resolving uncertainties in the risk estimates for radiation induced cancer which are the basis of protection regulations. Updated cancer incidence and mortality data from the epidemiological follow-up of the atomic bomb survivors and from medical cohorts will be analysed, and the results will be used for improved risk models. The major open questions concern the pattern of cancer risk in different tissues over lifetime and the dependences on age at exposure, dose, radiation quality, and temporal distribution of exposure. The proposed research contains several tasks. A first task (University of Munich) is the development of improved statistical and numerical methods for risk modelling. This includes the development, and the implementation in generally available software, of an algorithm that allows modelling of acute as well as continued exposures, and that permits the maximum likelihood evaluation of features, such as the distribution of latent periods. In a further refinement the algorithms will be extended to permit non-parametric modelling. A second task (INSERM, Villejuif, NRPB, Chilton) consists in the statistical analysis and the numerical quantification of uncertainties in risk estimates in their dependence on errors in dose estimates and model parameters. The methods resulting from both tasks will, in cooperation of the different groups, be applied to the data from the radioepidemiological studies to generate improved risk models for use in radiation protection with special emphasis on age dependences, the projection of risk in time, and the transfer of risk estimates between populations. A third task (NRPB, Chilton) is the study and improvement of mechanistic models of radiation induced cancer and the comparison of these models with the empirical results. In view of the critical importance in radiation protection of risk estimates for exposures early in life, two hospitals in Sweden (Karolinska Hospital, Stockholm, Sahlgren`s Hospital, Gothenburg) and one institution in France (Institut Gustave-Roussy, Villejuif) will cooperate on a newly defined large cohort of children who were radiation exposed for the treatment of skin hemangioma. Precise organ dependent dosimetry will be established for this cohort and cancer incidence will be assessed and followed further. The resulting dependences on age, time, tumor location and dose will be compared to the data from the atomic bomb survivors, to obtain improved cancer risk estimates for radiation exposure in childhood. Programme(s) EAEC-NFS 2 - Specific research and training programme in the field of nuclear safety and safeguards, 1994-1998 Topic(s) 040104 - Epidemiology and exposed populations Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator LUDWIG-MAXIMILIANS UNIVERSITY OF MUNICH EU contribution No data Address Schillerstrasse 42 80336 MUENCHEN Germany See on map Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all Institut Gustave Roussy France EU contribution No data Address 39,Rue Camille Desmoulins 94805 Villejuif See on map Total cost No data Institut National de la Santé et de la Recherche Médicale (INSERM) France EU contribution No data Address 16 avenue Paul Vaillant Couturier 94807 Villejuif See on map Total cost No data Karolinska Institute Sweden EU contribution No data Address 171 76 Stockholm See on map Total cost No data NATIONAL RADIOLOGICAL PROTECTION BOARD United Kingdom EU contribution No data Address OX11 0RQ DIDCOT,HARWELL,CHILTON See on map Total cost No data University of Göteborg Sweden EU contribution No data Address Sahlgrenska 413 45 Göteborg See on map Total cost No data
